Table 5 Results of two-way repeated-measures MANOVA (FBTCS− versus FBTCS+ remote versus FBTCS+ current) for the Z scores of subsystem integration between the four subcortical/cortical subsystem combinations (thalamus, striatum, mesial-temporal and cerebellar subsystems with all cortical subsystems).

From: Multiple subcortical and subcortico–cortico dynamic network reconfigurations characterize focal-to-bilateral tonic–clonic seizures

Source	df or Hypothesis df/error df	F	Sig	Partial Eta Squared	Observed Power
Between anterior thalamus/cortical subsystems
^gWS Hemisphere	1	6.260	0.016	0.107	0.690
WS Hemisphere X Group	2	0.833	0.440	0.031	0.185
WS Subsystems X Group	9.893	0.841	0.588	0.031	0.439
WS Hemisphere X Subsystem	6.656	0.880	0.518	0.017	0.370
WS Hemisphere X Subsystem X Group	13.312	0.675	0.791	0.025	0.419
BTWS Group	2/52	0.064	0.939	0.002	0.059
Between posterior thalamus/cortical subsystems
WS Hemisphere	1	0.048	0.827	0.001	0.055
WS Hemisphere X Group	2	0.146	0.864	0.006	0.071
WS Subsystems X Group	12.874	0.608	0.846	0.023	0.367
^hWS Hemisphere X Subsystem	5.630	2.893	0.011	0.053	0.876
WS Hemisphere X Subsystem X Group	11.259	0.922	0.521	0.034	0.520
BTWS Group	2/52	0.153	0.859	0.006	0.072
Between Putamen/cortical subsystems
ⁱWS Hemisphere	1	3.357	0.073	0.061	0.436
WS Hemisphere X Group	2	0.145	0.865	0.006	0.071
WS Subsystems X Group	9.415	1.132	0.340	0.042	0.570
WS Hemisphere X Subsystem	5.881	1.134	0.342	0.021	0.442
WS Hemisphere X Subsystem X Group	11.762	0.971	0.476	0.036	0.561
BTWS Group	2/52	0.091	0.914	0.003	0.063
Between Caudate/cortical subsystems
WS Hemisphere	1	0.652	0.423	0.012	0.125
^jWS Hemisphere X Group	2	4.173	0.021	0.138	0.710
^kWS Subsystems X Group	9.067	1.935	0.048	0.069	0.836
WS Hemisphere X Subsystem	6.487	1.331	0.239	0.025	0.544
WS Hemisphere X Subsystem X Group	12.974	0.545	0.895	0.021	0.328
BTWS Group	2/52	0.418	0.661	0.016	0.114
Between Globus Pallidus/cortical subsystems
WS Hemisphere	1	1.318	0.256	0.025	0.203
WS Hemisphere X Group	2	0.052	0.950	0.002	0.057
WS Subsystems X Group	10.382	0.623	0.799	0.023	0.331
WS Hemisphere X Subsystem	6.257	1.297	0.256	0.024	0.520
WS Hemisphere X Subsystem X Group	12.515	0.642	0.812	0.024	0.382
BTWS Group	2/52	0.060	0.942	0.002	0.059
Between Nucleus Accumbens/cortical subsystems
WS Hemisphere	1	0.252	0.618	0.005	0.078
WS Hemisphere X Group	2	0.243	0.786	0.009	0.086
WS Subsystems X Group	11.389	0.412	0.954	0.016	0.229
WS Hemisphere X Subsystem	6.738	1.566	0.147	0.029	0.640
WS Hemisphere X Subsystem X Group	13.476	0.883	0.574	0.033	0.554
BTWS Group	2/52	0.084	0.920	0.003	0.062
Between Anterior hippocampus/cortical subsystems
WS Hemisphere	1	0.922	0.341	0.017	0.156
WS Hemisphere X Group	2	0.474	0.625	0.018	0.123
WS Subsystems X Group	9.124	0.675	0.733	0.025	0.334
^lWS Hemisphere X Subsystem	5.670	1.881	0.088	0.035	0.677
WS Hemisphere X Subsystem X Group	11.341	0.661	0.780	0.025	0.371
BTWS Group	2/52	0.213	0.809	0.008	0.082
Between Posterior hippocampus/cortical subsystems
WS Hemisphere	1	0.021	0.887	0.000	0.052
WS Hemisphere X Group	2	1.076	0.348	0.040	0.229
WS Subsystems X Group	10.473	0.734	0.699	0.027	0.395
^mWS Hemisphere X Subsystem	6.076	5.113	0.000	0.090	0.994
WS Hemisphere X Subsystem X Group	12.152	1.284	0.226	0.047	0.725
BTWS Group	2/52	1.272	0.289	0.047	0.264
Between Amygdala/cortical subsystems
WS Hemisphere	1	0.003	0.956	0.000	0.050
WS Hemisphere X Group	2	0.072	0.931	0.003	0.060
WS Subsystems X Group	9.767	1.102	0.361	0.041	0.567
ⁿWS Hemisphere X Subsystem	5.507	1.866	0.093	0.035	0.663
WS Hemisphere X Subsystem X Group	11.015	1.081	0.376	0.040	0.597
BTWS Group	2/52	0.638	0.532	0.024	0.151
Between Cereb1/cortical subsystems
WS Hemisphere	1	2.112	0.152	0.039	0.297
WS Hemisphere X Group	2	0.004	0.996	0.000	0.051
WS Subsystems X Group	10.360	1.110	0.354	0.041	0.590
^oWS Hemisphere X Subsystem	5.765	2.274	0.039	0.042	0.778
WS Hemisphere X Subsystem X Group	11.529	1.295	0.223	0.047	0.712
BTWS Group	2/52	0.201	0.818	0.008	0.080
Between Cereb2/cortical subsystems
^pWS Hemisphere	1	7.349	0.009	0.124	0.758
WS Hemisphere X Group	2	0.064	0.938	0.002	0.059
WS Subsystems X Group	11.076	0.946	0.497	0.035	0.528
WS Hemisphere X Subsystem	6.041	1.195	0.322	0.022	0.462
WS Hemisphere X Subsystem X Group	12.081	0.655	0.795	0.025	0.382
BTWS Group	2/52	0.447	0.642	0.017	0.119
Between Cereb3/cortical subsystems
WS Hemisphere	1	2.312	0.134	0.043	0.320
WS Hemisphere X Group	2	0.066	0.936	0.003	0.059
WS Subsystems X Group	10.786	0.817	0.621	0.030	0.449
WS Hemisphere X Subsystem	5.982	0.919	0.481	0.017	0.363
WS Hemisphere X Subsystem X Group	11.964	0.785	0.665	0.029	0.459
BTWS Group	2/52	0.495	0.612	0.019	0.127
Between Cereb4/cortical subsystems
WS Hemisphere	1	0.001	0.982	0.000	0.050
WS Hemisphere X Group	2	2.207	0.120	0.078	0.431
WS Subsystems X Group	10.856	0.786	0.653	0.029	0.433
WS Hemisphere X Subsystem	5.628	0.553	0.757	0.011	0.214
WS Hemisphere X Subsystem X Group	11.256	0.820	0.623	0.031	0.462
BTWS Group	1/109	0.598	0.553	0.022	0.144
Between Cereb5/cortical subsystems
WS Hemisphere	1	0.051	0.822	0.001	0.056
WS Hemisphere X Group	2	0.390	0.679	0.015	0.110
^qWS Subsystems X Group	10.910	1.684	0.077	0.061	0.828
^rWS Hemisphere X Subsystem	6.179	2.791	0.011	0.051	0.886
WS Hemisphere X Subsystem X Group	12.357	0.516	0.908	0.019	0.301
BTWS Group	2/52	0.939	0.397	0.035	0.204
Between Cereb6/cortical subsystems
^sWS Hemisphere	1	7.429	0.009	0.125	0.763
WS Hemisphere X Group	2	0.886	0.418	0.033	0.195
WS Subsystems X Group	10.847	1.018	0.430	0.038	0.559
WS Hemisphere X Subsystem	6.290	0.903	0.496	0.017	0.367
WS Hemisphere X Subsystem X Group	12.579	0.592	0.856	0.022	0.352
BTWS Group	2/52	1.442	0.246	0.053	0.295
Between Cereb7/cortical subsystems
^tWS Hemisphere	1	4.956	0.030	0.087	0.589
WS Hemisphere X Group	2	1.532	0.226	0.056	0.311
WS Subsystems X Group	10.148	1.015	0.431	0.038	0.537
WS Hemisphere X Subsystem	6.793	0.403	0.896	0.008	0.177
WS Hemisphere X Subsystem X Group	13.587	0.610	0.852	0.023	0.381
BTWS Group	2/52	0.764	0.471	0.029	0.173

The univariate test results showing main effects and interactions of condition, experimental group, and subsystems for integration. Pairwise comparisons were also tested for the results showing a significant univariate effect to determine the nature of the differences between those variables (See suppl. section). WS—Within-subject effect, BTWS—Between-subject effect.
*Multivariate effect is significant at p < 0.05 or less.
Significant differences are highlighted in bold. Trends are italicized.

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