Fig. 3 | Scientific Reports

Fig. 3

From: Selective activation of antioxidant resources and energy deficiency in Marinesco–Sjögren syndrome fibroblasts as an adaptive biological response to Sil1 loss

Fig. 3

Activation of the antioxidant response in MSS fibroblasts. (A,B) Both graphs show gene expression of SOD1 and SOD2 measured by real-time PCR using ΔΔCt method. (C,D) Western blot analysis of SOD1 and SOD2 in patient-derived fibroblasts (MSS) and controls (CT) shows a significant increase of SOD2 in MSS cells compared to CT cells. (E,F) The enzymatic activity of both antioxidant enzymes (SOD1 and SOD2) shows a significant raise in the pathological condition as well as the total SOD activity (G). Statistical analysis was performed using an unpaired t-test with Welch’s correction (*P < 0.05, ***P < 0.001).

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