Fig. 4

Activation of the antioxidant response and scavenging efficiency of CAT/SOD system in MSS fibroblasts. (A,B) Gene expression and protein expression of CAT. (C) Enzymatic activity of CAT in controls (CT) and in patient-derived fibroblasts (MSS) shows a significant increase in MSS cells. (D–F) Measurement of scavenging efficiency of CAT/SOD system using ratios between the enzymes. Statistical analysis was performed using an unpaired t-test with Welch’s correction (*P < 0.05, **P < 0.01, ***P < 0.001).