Fig. 1
From: Role of alpha-1 antitrypsin in Bruch’s membrane integrity
AAT–/– mice exhibited normal age-related pathologies at 18-24 M. (a) Fundus images and corresponding OCT scans (green line) show microglia migration (cyan arrows, top panel). In one aged AAT–/– mouse (bottom row), the retina developed GA (red arrow) and neovascular pathologies as seen by OCT and FFA, respectively. Scale bar: 100 μm. (b) Percentage distribution of microglia and disease phenotypes shown in (a) in AAT–/– mice at 18-24 M of age. Bars show percentage ± margin of error (M.O.E.). Numbers in parentheses indicate the number of eyes analyzed.
