Table 1 Effect of C. roseus on the body weight of diabetes model mice.

From: Unlocking the therapeutic potential of Catharanthus roseus leaves via in-vitro, in-vivo, and in-silico study

Treatment groups

Body weight (gm)

Day 01

Day 5

Day 10

Day 15

Day 20

Normal control

29.75 ± 3.15

30.87 ± 2.34

33.26 ± 2.22

35.06 ± 1.87

36.43 ± 1.70

Diabetic Control

28.79 ± 2.5

29.49 ± 1.65a

32.06 ± 2.18 a

26.54 ± 1.24 a

24.14 ± 2.69 a

MET

32.75 ± 2.64

29.87 ± 0.94

26.34 ± 2.32

23.21 ± 2.36

22.89 ± 2.58

GBN

30.75 ± 1.88

29.05 ± 2.42

31.65 ± 3.02

33.67 ± 2.23*

34.87 ± 3.65**

MCR 100

32.45 ± 2.93

31.21 ± 2.56

32.34 ± 3.19

33.67 ± 2.43*

33.01 ± 2.59*

MCR 200

29.23 ± 2.67

28.65 ± 2.45

31.89 ± 3.67

32.47 ± 3.69

34.58 ± 4.26*

ECR 100

31.08 ± 3.51

29.67 ± 4.96

31.08 ± 3.09

33.36 ± 3.78*

34.92 ± 2.38**

ECR 200

29.98 ± 2.87

30.1 ± 1.76

33.78 ± 4.62

34.95 ± 2.36*

36.01 ± 3.61**

DCR 100

30.58 ± 3.18

28.85 ± 4.19

29.78 ± 5.56

31.75 ± 3.49

32.00 ± 2.65

DCR 200

29.86 ± 2.68

30.27 ± 2.89

31.98 ± 1.48

33.97 ± 1.91

34.23 ± 2.03*

  1. MET = Metformin hydrochloride, GBN = Glibenclamide, MCR = Methanol extract of C. roseus, ECR = Ethanol extract of C. roseus, DCR = Dichloromethane fraction of C. roseus.
  2. [Each value represents the mean ± SEM (n = 6 animals per group)].
  3. aRepresents statistical significance vs. normal control (p < 0.05).
  4. *Represents statistical significance vs. diabetic control (p < 0.05).
  5. **Represents statistical significance vs. diabetic control (p < 0.01).
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