Table 2 Univariate and multivariate Cox regression analyses based on the SEER database cohort.
Characteristics | Univariate Cox regression | Multivariate Cox regression | ||||
|---|---|---|---|---|---|---|
HR | CI | P value | HR | CI | P valuea | |
Gender | ||||||
Male/Female | 1.04 | 1.01–1.06 | 0.005 | 1.14 | 1.10–1.18 | < 0.001 |
Age (years) | ||||||
≥ 65/<65 | 2.51 | 2.44–2.57 | < 0.001 | 2.02 | 1.94–2.09 | < 0.001 |
Race | ||||||
Non-whiteb/White | 0.88 | 0.86–0.91 | < 0.001 | 0.94 | 0.91–0.98 | 0.004 |
T stage | ||||||
T3&T4/T1&T2 | 2.13 | 2.04–2.22 | < 0.001 | 1.65 | 1.55–1.75 | < 0.001 |
AJCC N stage | ||||||
N2/N1 | 1.62 | 1.58–1.66 | < 0.001 | 1.33 | 1.27–1.38 | < 0.001 |
Examined lymph nodes | ||||||
≥ 14/<14 | 0.76 | 0.74–0.78 | < 0.001 | 0.81 | 0.78–0.84 | < 0.001 |
modified N stage | ||||||
mN2/mN1 | 2.19 | 2.13–2.25 | < 0.001 | 1.66 | 1.58–1.74 | < 0.001 |
Tumor Deposits | ||||||
Yes/No | 1.65 | 1.61–1.70 | < 0.001 | 1.39 | 1.34–1.44 | < 0.001 |
Perineural invasion | ||||||
Positive/Negative | 1.53 | 1.49–1.58 | < 0.001 | 1.33 | 1.28–1.38 | < 0.001 |
Carcinoembryonic antigen | ||||||
Positive/Negative | 1.62 | 1.57–1.67 | < 0.001 | 1.39 | 1.35–1.44 | < 0.001 |
Adjuvant chemoradiotherapy | ||||||
Yes/No | 0.37 | 0.36–0.38 | < 0.001 | 0.39 | 0.38–0.40 | < 0.001 |
Neoadjuvant therapy | ||||||
Yes/No | 0.83 | 0.79–0.87 | < 0.001 | 0.71 | 0.67–0.76 | < 0.001 |
