Fig. 6
The progression of cell cycle for THP-1 cells after 24-h treatment with different doses of AsA and X-radiation. (A) The bar chart of THP-1 cells illustrated all phases of cell cycle after the treatment. Data are presented as Mean ± Standard deviation. P-value < 0.05, That indicated by ***: 0.001, **: 0.01, *: 0.05. As radiation dose increases, the percentage of cells in the S phase decreases, suggesting a significant inhibition of DNA synthesis. This decline implies that fewer cells are progressing through the replication phase, reinforcing the impact of G0/G1 arrest, the proportion of cells in the G2/M phase decreases indicating that fewer cells are reaching mitosis. (B) Cell cycle analysis of THP-1 cells following treatment with AsA andradiation. the histograms demonstrated the distribution of cells across different phases (G1, S, G2/M) the data suggest alterations in cell cycle progression depending on the dose of AsA and radiation exposure, highlighting a potential synergistic effect on cell cycle arrest.
