Fig. 2

CST6 protein concentration is increased while LGMN protein concentration in plasma is unchanged in patients with early-onset preeclampsia (< 34 weeks’ gestation). (A) CST6 protein concentration was measured via ELISA relative to gestation-matched controls (n = 27, orange bar), in placentas obtained from patients with early-onset preeclampsia (n = 35, blue bar). (B) LGMN protein concentration was measured in the same cohort, and no change in protein concentration was observed. (C) CST6 levels were significantly increased with no significant association with gestational age at collection for both the control (r² = 0.0023, p = 0.8131) and preeclampsia (r² = 0.0029, p = 0.7676) groups. (D) There was no significant association between LGMN protein concentration and gestational age at collection for both the control (r² = 0.0382, p = 0.3387) and preeclampsia (r² = 0.0003, p = 0.9228) groups. Each dot represents individual participants. The significance of the data was determined by a Mann–Whitney U test and a simple linear regression was used to determine the association of CST6 and LGMN expression/concentration with gestation at blood collection. Data is expressed as median ± interquartile range. * p < 0.05.