Fig. 3

CST6 protein concentration was increased while LGMN protein concentration was decreased in patients preceding diagnosis of preeclampsia (36 weeks’ gestation). (A) In the BUMPS cohort, circulating CST6 was increased in women who developed preeclampsia at term (n = 21) compared to gestation-matched controls (n = 184). (B) In the same cohort, circulating LGMN was decreased in women who developed preeclampsia at term compared to gestation-matched controls. (C) The ratio of CST6/LGMN was plotted and, in the same cohort, was increased in women who developed preeclampsia at term compared to gestation-matched controls. Area under the receiver operator curve (AUC) of (D) 0.71, (E) 0.67 and (F) 0.73. Each dot represents individual participants. The significance of the data was determined using a Mann–Whitney U test. Data is presented as median ± interquartile range. *** P < 0.001, ** P < 0.01, * P < 0.05.