Fig. 7
From: Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia
Regulation of CST6 and LGMN expression in syncytiotrophoblast cells. (A) CST6 expression was significantly increased in syncytiotrophoblast cells incubated in a hypoxic environment (1% O2) compared to control normoxic environment (8% O2). (B) LGMN expression was unchanged when incubated in a hypoxic environment relatively to control. mRNA expression was normalised to the geometric mean of housekeeper genes or single housekeeping gene depending on the treatment. To calculate significance, one-way ANOVA or Unpaired t test (parametric) or a Kruskal Wallis test (non-parametric) was used. Data expressed as mean ± SEM for experiments. Experiments repeated n = 5 in triplicate. *** p < 0.001.
