Fig. 8
From: Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia
Induced endothelial dysfunction in HUVECs has no effect on LGMN expression but decreases CST6 expression. Successful induction of endothelial dysfunction in HUVECs was confirmed by significant increase of: (A) VCAM1 (B) ET-1 and (C) ICAM1. (D) CST6 expression in HUVECs was significantly decreased following treatment with increased doses of TNFα. (E) LGMN mRNA expression was unchanged. mRNA expression was normalised to the appropriate housekeeping gene. To calculate significance, Kruskal Wallis test was used. Data expressed as mean ± SEM. Experiments repeated n = 5 in duplicate. ** p < 0.01, *p < 0.05.
