Fig. 5 | Scientific Reports

Fig. 5

From: Targeting the proliferation of glioblastoma cells and enhancement of doxorubicin and temozolomide cytotoxicity through inhibition of PFKFB4 and HMOX1 genes with siRNAs

Fig. 5

(A) The scatter plot illustrates the changes in gene expression for the siPFKFB4 100 nM treatment group, with up-regulated genes marked by red dots and down-regulated genes represented by green dots. (B) Another scatter plot highlights the gene expression alterations observed in the siPFKFB4 100 nM combined with the DOX IC50 group, employing the same color scheme for clarity. (C) This plot depicts gene expression patterns for the DOX IC50 group, once more using red dots for up-regulated genes and green dots for those that are down-regulated. (D) Finally, the scatter plot for the siHMOX1 100 nM group shows gene expression changes, with up-regulated genes indicated in red and down-regulated genes in green, specifically highlighting those with a fold change of ≥ 2 and a p-value of < 0.05.

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