Fig. 7 | Scientific Reports

Fig. 7

From: Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions

Fig. 7

Spleen inflammation is increased in adipocyte-specific Mipep knockout (aMKO) mice. Inflammation of spleens from 27-week-old control and aMKO mice. (A,B) Representative flow cytometry dot plots showing the myeloid cell landscape in spleens. (A) The upper panel shows the Gr-1 versus CD11b (left) and F4/80 versus CD11b (right) staining profile gated by CD45+ cells. The lower panel shows the absolute numbers of CD11b+ Gr-1low monocytes, CD11b+ Gr-1high granulocytes, and CD11b+ F4/40+ macrophages. (B) The upper panel shows the B220 versus CD3 (left) and CD8 versus CD4 (right) staining profile gated by CD45+ cells. The lower panel shows the absolute number of B220− CD3+ T cells and B220+ CD3− B cells. Each dot represents one mouse. Values are mean ± SD. Differences between values were analyzed by Student’s t-test. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. control. CD, cluster of differentiation; Gr, granulocyte.

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