Fig. 8 | Scientific Reports

Fig. 8

From: Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions

Fig. 8

Glucose and insulin sensitivity is impaired and hepatic steatosis is increased in adipocyte-specific Mipep knockout (aMKO) mice. (A,B) Blood glucose levels during a GTT (A) and ITT (B) in 21–24-week-old control and aMKO mice. AUCs were calculated and are shown in the right panel. (C) Hematoxylin and eosin staining of livers from 27-week-old control and aMKO mice. Scale bar: 100 μm. (D) TG contents of livers from 27-week-old control and aMKO mice. Each dot represents one mouse. Values are mean ± SD. Differences between values were analyzed by Student’s t-test. *p < 0.05 and **p < 0.01. AUC, area under the curve; GTT, glucose tolerance test; ITT, insulin tolerance test; TG, triglyceride.

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