Table 2 Plasma biochemical data and cyto(mito)kine levels of adipose-specific Mipep knockout (aMKO) mice.

From: Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions

Plasma

  

Control

aMKO

 

TG

(mg/dL)

78.428 ± 12.592

95.010 ± 12.592

0.050

NEFA

(mEq/L)

0.196 ± 0.107

0.131 ± 0.074

 

Cholesterol

(mg/dL)

68.355 ± 11.083

76.083 ± 12.360

 

Glucose

(mg/dL)

549.148 ± 93.880

672.291 ± 81.092

*

Adiponectin

(µg/mL)

45.165 ± 1.178

32.102 ± 3.128

***

Leptin

(ng/mL)

1.975 ± 0.886

1.108 ± 0.758

 

Insulin

(pg/mL)

271.554 ± 25.530

780.792 ± 358.372

**

GDF15

(pg/mL)

63.729 ± 6.430

132.590 ± 23.334

***

FGF21

(pg/mL)

306.326 ± 188.296

389.019 ± 96.508

 

IL-1b

(pg/mL)

1.464 ± 0.220

2.628 ± 1.082

*

CXCL2

(pg/mL)

107.488 ± 78.824

63.543 ± 51.797

 

CXCL5

(pg/mL)

516.974 ± 334.726

1736/27 ± 1435.66

0.091

  1. Biochemical and cyto(mito)kine levels in the plasma of 27-week-old control and aMKO mice. TG, NEFA, cholesterol, glucose, adiponectin, leptin, insulin, GDF15, and FGF21 were measured by ELISA. Values are mean ± SD (n = 4–9/group). Differences between values were analyzed by Student’s t-test. *p < 0.05, **p < 0.01 and ***p < 0.001 vs. control. CXCL, chemokine ligand; FGF21, fibroblast growth factor 15; GDF15, growth differentiation factor 15; IL-1b, interleukin 1 beta; NEFA, non-esterified fatty acids; TG, triglyceride.
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