Fig. 4

Quantitative performance assessment on (a) colorectal, (b) liver, and (c) lung cancer validation cohorts. ROC curves represent the predictions of the corresponding models (left). Likelihood ratio plots show the likelihood ratios of corresponding models on the full cohort and the subgroup of patients having at least nine out of the top 15 markers available, for increasing risk thresholds (middle). Likelihood ratio curves are compared to those of baseline models that are either based on the total number of OoR markers (middle) or single markers (right), corresponding to the top five markers for each cancer type (cf. Fig. 5), including age for CRC. Thin lines depict likelihood ratio curves of base models, while ribbons correspond to one standard deviation of their likelihood ratios. ALP alkaline phosphatase, MCH mean corpuscular hemoglobin, MCV mean corpuscular volume, RDW red cell distribution width.