Fig. 6

Comorbidity analysis on (a) colorectal, (b) liver, and (c) lung cancer validation cohorts. Likelihood ratio plots show the likelihood ratios of corresponding models on subgroups of patients suffering from the indicated comorbidities, for increasing risk thresholds on the testing dataset. Barplots illustrate the significance of association of the corresponding comorbidity with cancer type (as negative logarithm of the p-value obtained with Fisher’s exact test) over the entire dataset. The prevalence of the respective comorbidities in the cancer-positive and control cases is listed with each comorbidity. Note that the base prevalence is different for each comorbidity. GI gastrointestinal.