Fig. 4

HCC Overall Survival based on sHLA-G levels. The overall survival of HCC-specific mortality is graphically presented for a cohort of 116 patients observed over a 60-months time frame. Patients were categorized based on their soluble HLA-G (sHLA-G) in low (< 25 U/mL) medium (25–80 U/mL) or high (> 80 U/mL) levels. P-values were calculated using the two-sided log-rank test. A) Overall Survival based on sHLA-G levels in patients with HCC related to HCV and/or HBV infection The overall survival (OS) of HCC-specific mortality is graphically presented for a cohort of 95 patients observed over a 60-months time frame. Patients were categorized based on their soluble HLA-G (sHLA-G) in low (< 25 U/mL) medium (25–80 U/mL) or high (> 80 U/mL) levels. P-values were calculated using the two-sided log-rank test. B) Overall Survival based on sHLA-G levels in patients with HCC SLD related The overall survival (OS) of HCC-specific mortality is graphically presented for a cohort of 21 patients observed over a 60-months time frame. Patients were categorized based on their soluble HLA-G (sHLA-G) in low (< 25 U/mL) medium (25–80 U/mL) or high (> 80 U/mL) levels. P-values were calculated using the two-sided log-rank test. This HCC patients subgroup included ALD and MASLD/MASH. Abbreviations: SLD = Steatotic liver disease; ALD = Alcoholic liver 330 disease; MASLD = Metabolic dysfunction associated steatotic liver disease; MASH = Metabolic dysfunction associated steatohepatitis.