Table 2 Extended haplotypes (HLA-G alleles and 3’UTR haplotypes) frequencies in healthy controls and HCC patients.

From: Human leukocyte antigen-G in hepatocellular carcinoma driven by chronic viral hepatitis or steatotic liver disease

Extended haplotypes

140

Healthy controls

116HCC patients

Patients vs Controls

Alleles

3’UTR haplotype

2 N = 280

f

2 N = 232

f

P value

OR

95% CI

G*01:01:01:01

UTR-1

77

0.275

49

0.211

0.100

0.706

0.468–1.064

G*01:03:01:02

UTR-5

43

0.154

29

0.125

0.374

0.787

0.474–1.307

G*01:01:02:01

UTR-2

33

0.118

36

0.155

0.243

1.375

0.827–2.285

G*01:01:03:03

UTR-7

19

0.068

22

0.095

0.327

1.439

0.759–2.730

G*01:01:01:08

UTR-1

18

0.064

26

0.112

0.059

1.837

0.980–3.443

G*01:01:22:01

UTR-2

18

0.064

10

0.043

0.333

0.656

0.297–1.450

G*01:01:01:05

UTR-4

14

0.05

13

0.056

0.843

1.128

0.519–2.450

G*01:04:01:01

UTR-3

15

0.05

21

0.086

0.111

1.792

0.885–3.494

G*01:06:01:01

UTR-2

10

0.028

2

0.009

0.121

0.296

0.051–1.082

G*01:05 N

UTR-2

5

0.018

7

0.03

0.393

1.711

0.536–5.464

G*01:04:04

UTR-3

5

0.018

1

0.0043

0.228

0.238

0.028–2.053

G*01:01:01:04

UTR-18

5

0.018

0

0

0.067

0.000

-

G*01:04:01:01

UTR-10

3

0.011

0

0

0.256

0.000

-

G*01:06:01:02

UTR-2

2

0.0071

3

0.0129

0.663

1.821

0.302–10.991

G*01:01:01:06

UTR-4

2

0.0071

0

0

0.503

0.000

-

G*01:04:01:02

UTR-3

2

0.0071

1

0.0043

1.000

0.602

0.054–6.678

G*01:01:01:01

UTR-4

1

0.0036

0

0

1.000

0.000

-

G*01:01:01:04

UTR-6

1

0.0036

0

0

1.000

0.000

-

G*01:01:01:06

UTR-2

1

0.0036

0

0

1.000

0.000

-

G*01:06:02:02

UTR-2

1

0.0036

0

0

1.000

0.000

-

G*01:01:01:01

UTR-3

1

0.0036

0

0

1.000

0.000

-

G*01:03:01:01

UTR-5

1

0.0036

0

0

1.000

0.000

-

G*01:02:02

UTR-2

1

0.0036

0

0

1.000

0.000

-

G*01:03:01:01

UTR-2

1

0.0036

0

0

1.000

0.000

-

G*01:01:01:09

UTR-1

1

0.0036

1

0.0043

1.000

1.208

0.075–19.416

G*01:01:01:13

UTR-6

0

0

2

0.0086

0.205

-

-

G*01:01:01:01

UTR-6

0

0

1

0.0043

0.453

-

-

G*01:01:17

UTR-2

0

0

1

0.0043

0.453

-

-

G*01:04:01:01

UTR-2

0

0

2

0.0086

0.205

-

-

G*01:03:01:02

UTR-13

0

0

2

0.0086

0.206

-

-

G*01:01:22:01

UTR-10

0

0

1

0.0043

0.453

-

-

  1. P values were calculated for comparisons between HCC patients and the healthy control group. Abbreviations: OR, odds ratio; CI,confidence interval; f = allele frequencies expressed as decimals.
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