Table 1 Diagnostic performance of assays in Vit B12 quantification.

From: Accre 8 emerging point of care CLIA system for vitamin B12 assessment compared with three established assays

Reference

Test

Specificity (%)

Sensitivity (%)

PPV (%)

NPV (%)

Cohen’s Kappa Coefficient

    

(CI: 95%)

  

LC-MS/MS

Abbott

100%

(97.1–100)

77.7%

(69.1–84.4)

100%

(95.8–100)

100%

(76.8–88.6)

0.78

(0.71–0.86)

LC-MS/MS

Accre 8

86.7%

(80.8–90.9)

96.9%

(89.6–99.5)

73.6%

(63.4–81.7)

98.7%

(95.3–99.8)

0.76

(0.67–0.84)

LC-MS/MS

Roche

99.3%

(96.1–99.9)

88.7%

(80.8–93.6)

98.9%

(93.8–99.9)

92.8

(87.5–95.9)

0.80

(0.70–0.91)

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