Fig. 10 | Scientific Reports

Fig. 10

From: PDT-regulated immune gene prognostic model reveals tumor microenvironment in colorectal cancer liver metastases

Fig. 10

PDT affects the immune function of CRC. (A) Functional enrichment results of marker genes of various cells in the colorectal cancer immune microenvironment. (B) The trends of PD-1 and PD-L1 in the three types of tissues were consistent with the trends of macrophage proportion. (C) Riskscores were positively correlated with the expression of PDCD1 and CD274 in TCGA colorectal cancer mRNA sequencing data. (D,E) Relative to the low-risk group, the range and amount of PDCD1/CD274 expression were higher in the high-risk scoring group and were consistent with the expression of some immune cells. (F) IHC results of mouse MC38 cell line subcutaneous transplantation tumors. The expression and range of CD68 were significantly lower in the PDT group compared with the control group.

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