Fig. 2 | Scientific Reports

Fig. 2

From: Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming

Fig. 2

Mesoderm potentiation increases differentiation efficiency. (A) Differentiated iPS were labeled for cardiac troponin T (cTnT), myosin light chain 2v (MLC2V), and myosin light chain 2a (MLC2A). (B) MLC2V, MLC2A, and cTnT positivity were all increased following T transfection. (C) MLC2V was positivity preferentially increased with mesoderm priming before differentiation. *p < 0.05, ***p < 0.001 T + CHIR denotes cells transfected with T that undergo biphasic Wnt modulation for cardiac differentiation. CHIR denotes untransfected cells that are differentiated with Wnt modulation.

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