Fig. 5 | Scientific Reports

Fig. 5

From: Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming

Fig. 5

T transfected cells display more mature action potential morphologies. Untransfected (A) and T transfected (B) cells were stained with FluoVolt for assessing action potential morphology with 2 Hz external field stimulation. (C) Superimposed averaged action potential traces reveal distinct action potential shape between culture conditions. Action potential duration 70 is increased in T transfected cells (D) with an increase in maximum upstroke velocity (E) and enhanced minimum repolarization slope (F) and a lower decay constant, tau (G). T + CHIR denotes cells transfected with T that undergo biphasic Wnt modulation for cardiac differentiation. CHIR denotes untransfected cells that are differentiated with Wnt modulation.

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