Table 1 Optimization table.

From: Room temperature, metal-free, CDI-promoted, ex-situ protocol for S-methyl thioester synthesis

  1. [a]Unless specified, reaction conditions are: In Chamber 1 added 1.0 mmol of carboxylic acid 1a, 1.2 mmol of CDI, 1.0 mL of CH3CN, stirred at 30 °C (RT) for 1 h. After 1 h in Chamber 2, added y mmol of 2a, z mL of xM NaOH, stirred at 30 °C (RT) for 3 h. [b]Isolated yields.
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