Table 1 Transduction rates of inner ear hair cells after the injection of various AAV serotypes at the embryonic stage.
AAV2 | AAV8 | Anc80L65 | AAV9-PHP.eB | p | |
|---|---|---|---|---|---|
IHC | n = 5 | n = 6 | n = 4 | n = 4 | |
Global | 29 ± 1.6 [25–32] | 24 ± 4.6 [11–43] | 41 ± 8.2 [25–63] | 21 ± 1.9 [16–25] | 0.064 |
Apex | 4 ± 4 [0–12] | 12 ± 1.4 [7–16] | 30 ± 15.8 [0–53] | 3 ± 1.9 [0–7] | 0.099 |
Medial turn | 11 ± 6.8 [0–31] | 20 ± 10.2 [5–70] | 31 ± 7.5 [14–50] | 3 ± 1.9 [0–7] | 0.018 |
Base | 64 ± 6.8 [46–84] | 38 ± 8.5 [15–57] | 62 ± 10.2 [35–79] | 57 ± 7.5 [41–76] | 0.16 |
OHC | n = 5 | n = 6 | n = 4 | n = 4 | |
Global | 31 ± 7.1 [16–50] | 44 ± 2.5 [38–50] | 62 ± 7.7 [41–76] | 17 ± 1.4 [15–21] | 0.002 |
Apex | 1 ± 0.7 [0–2] | 11 ± 1.3 [7–14] | 20 ± 7.7 [0–34] | 6 ± 2.2 [2–12] | 0.046 |
Medial turn | 13 ± 8.8 [0–37] | 56 ± 15.3 [11–79] | 79 ± 14.1 [37–98] | 9 ± 2.3 [4–14] | 0.004 |
Base | 60 ± 11.2 [40–92] | 52 ± 3.2 [46–57] | 88 ± 11.1 [54–100] | 37 ± 2.4 [30–40] | 0.003 |
VHC | n = 5 | n = 6 | n = 4 | n = 4 | |
Global | 20 ± 4.8 [1–50] | 66 ± 6.1 [20–90] | 63 ± 8.5.5 [32–92] | 45 ± 3.3 [30–68] | < 0.0001 |
Ampulla | 11 ± 4.1 [1–22] | 52 ± 9.8 [20–80] | 64 ± 8.9 [32–80] | 50 ± 4.9 [33–68] | 0.0025 |
Macula | 30 ± 7 [20–50] | 76 ± 4.4 [67–90] | 63 ± 7.5 [45–92] | 39 ± 3.2 [30–53] | 0.0004 |
