Table 3 Transduction rates of inner ear hair cells after the injection of various AAV serotypes at early mature stage (P14-P18).

From: Cell tropism of adeno-associated viruses within the mouse inner ear in vivo: from embryonic to adult stages

 

AAV2

AAV8

Anc80L65

AAV9-PHP.eB

p

IHC

n = 10

n = 4

n = 6

n = 6

 

 Global

82 ± 5.5 [53–100]

72 ± 8.2 [55–96]

99 ± 0.9 [94–100]

98 ± 1.1 [93–100]

0.009

 Apex

79 ± 9.7 [1-100]

87 ± 7.6 [59–100]

99 ± 0.5 [96–100]

100 ± 0 [100–100]

0.014

 Medial turn

83 ± 8.3 [20–100]

77 ± 13.3 [51–100]

100 ± 0 [100–100]

100 ± 0 [100–100]

0.085

 Base

83 ± 7.1 [40–100]

58 ± 17.4 [10–93]

97 ± 3.3 [83–100]

94 ± 4.0 [80–100]

0.079

OHC

n = 10

n = 4

n = 6

n = 6

 

 Global

29 ± 5.5 [4–58]

3.4 ± 1.5 [0–7]

7 ± 6.0 [0–31]

26 ± 4.7 [10–39]

0.007

 Apex

32 ± 8.1 [1–90]

2 ± 1.7 [0–5]

13 ± 8.9 [0–61]

33 ± 6.1 [10–50]

0.026

 Medial turn

37 ± 6.0 [10–65]

8 ± 3.5 [0–14]

1 ± 1.1 [0–4]

22 ± 5.8 (10–42)

0.004

 Base

19 ± 4.4 [1–36]

1 ± 0.6 [0–2]

0

24 ± 7.0 [5–39]

0.003

VHC

n = 7

n = 4

n = 5

n = 5

 

 Global

1 ± 0.4 [0–5]

8 ± 5.4 [0–34]

37 ± 9.6 [0–90]

25 ± 3.1 [6–38]

0.0004

 Ampulla

1 ± 0.3 [0–2]

13 ± 8.3 [0–34]

15 ± 6.9 [0–32]

24 ± 5.8 [6–38]

0.0004

 Macula

1 ± 0.8 [0–5]

4 ± 4 [0–24]

58 ± 11.8 [31–90]

26 ± 3.1 [18–35]

0.003

  1. The data shown are the mean ± SEM [range]. Statistical comparisons were performed by two-way ANOVA. N is the number of organs analyzed. IHC = inner hair cells; OHC = outer hair cells; VHC = vestibular hair cells.
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