Table 4 Transduction rates of inner ear hair cells after injections of various AAV serotypes at late mature stage (P30).
AAV2 | AAV8 | Anc80L65 | AAV9-PHP.eB | p | |
|---|---|---|---|---|---|
IHC | n = 5 | n = 5 | n = 6 | n = 5 | |
Global | 55 ± 10 [1-100] | 79 ± 6.3 [0-100] | 93 ± 2.8 [71–100] | 67 ± 10.5 [0–97] | 0.0031 |
Apex | 5 ± 2.9 [1–17] | 64 ± 16.4 [0–94] | 89 ± 6.8 [71–100] | 57 ± 22.3 [0–94] | 0.005 |
Medial turn | 63 ± 9.9 [26–79] | 83 ± 11.1 [39–95] | 98 ± 1.2 [96–100] | 75 ± 16.9 [25–97] | 0.2 |
Base | 95 ± 3.7 [80–100] | 81 ± 11.4 [42–100] | 94 ± 5.2 [79–100] | 69 ± 19.1 [12–93] | 0.3 |
OHC | |||||
Global | 11 ± 3.4 [0–53] | 8 ± 1.8 [0–19] | 13 ± 5.6 [0–66] | 0 | 0.046 |
Apex | 2.5 ± 1.4 [0–9] | 8 ± 4.2 [0–19] | 21 ± 13.1 [0–66] | 0 | 0.2 |
Medial turn | 21 ± 8.7 [0–53] | 8 ± 2.2 [0–13] | 15 ± 10.5 [0–62] | 0 | 0.2 |
Base | 10 ± 2.6 [0–16] | 9 ± 3.6 [1–19] | 4 ± 2.8 [0–17] | 0 | 0.035 |
VHC | |||||
Global | 0.5 ± 0.4 [0–7] | 3 ± 0.5 [0–9] | 33 ± 5.2 [3–55] | 7 ± 3.1 [0–32] | < 0.0001 |
Ampula | 0 | 3 ± 0.6 [0–5] | 18 ± 5.6 [3–40] | 5 ± 3.7 [0–28] | 0.011 |
Macula | 1 ± 0.7 [0–7] | 4 ± 0.9 [1–9] | 44 ± 5.3 [20–58] | 8 ± 5.4 [0–32] | < 0.0001 |
