Fig. 2

Mutation profile analysis of the different three subtypes in TCGA database. (A) Tumor mutation burden of the three subtypes. (B) Cancer-related signal pathways enrichment based on mutation profile. (C) Mutation frequency and mutation type of common mutated genes in all samples. (D–F) Mutation frequency and mutation type of common mutated genes in C1(D), C2(E) and C3(F) subtypes. The T test was used to determine differences between tumor and normal tissues. A p value of < 0.05 /<0.01/<0.001/ <0.0001 denoted by an asterisk */**/***/**** in figures.