Fig. 5
From: Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer
Effect of nanoparticles on prostate cancer cells. The heatmap illustrates the viability of PC cell lines (LNCaP, VCaP, DU-145, PC-3) and normal prostate epithelial cells (RWPE-1) following 24-h and 48-h treatments with different compounds: ethanol, polymer, DMSO, abiraterone, abiraterone nanoparticles, curcumin, curcumin nanoparticles, curcumin piperine nanoparticles, and piperine nanoparticles. Cell viability was assessed using the Alamar Blue assay and is represented as a percentage of the untreated control cells. The data points for each cell line and time point are averaged from the triplicate experiments. The results highlight the differential sensitivities of the cell lines to the treatments, with curcumin piperine nanoparticles showing significant reduction in viability in PC cell lines, especially in the 48-h treatments, while maintaining higher viability in normal RWPE-1 cells. The nanoparticle formulations of both curcumin and abiraterone exhibited enhanced efficacy compared to their free drug counterparts. Low viability (indicating higher cytotoxicity) is depicted in grey and high viability (indicating lower cytotoxicity) is depicted in blue.
