Fig. 6
From: Improved acid-driven inhibition of effector T cell function by a pHLIP variant-conjugated PD-L1
The schematic illustration on the mode of action of PD-L1-pHLIPva. PD-L1-pHLIPva, chemically ligating a pHLIP variant to the ectodomain of PD-L1 via sulfo-SMCC linker, has potency to actively inhibit T effector response via delivering PD-L1/PD-1 signals by spanning across the cellular membrane of neighboring non-T cells under nearly neutral conditions (pH6.8), while this cargo cannot insert into membrane in pH7.4 buffer, leading to the loss of immunosuppressive function.
