Table 5 Logistic regression analysis of 25(OH)D metabolites with CKD severity in RA patients.

From: 25(OH)D3 and F-25(OH)D as indicators of chronic kidney disease progression in patients with rheumatoid arthritis

Season

Moderate CKD*

Severe CKD*

OR (95%CI)

Wald χ2

P

OR (95%CI)

Wald χ2

P

All seasons (n = 1514)

25(OH)D3

0.956(0.931, 0.981)

11.255

0.001

0.895(0.861, 0.931)

30.942

< 0.001

F-25(OH)D

0.847(0.779, 0.922)

14.762

< 0.001

0.766(0.680, 0.864)

18.867

< 0.001

Spring (n = 558)

25(OH)D3

0.960(0.923, 0.999)

3.998

0.046

0.932(0.875, 0.991)

4.9778

0.026

F-25(OH)D

0.824(0.732, 0.928)

10.176

0.001

0.727(0.604, 0.875)

11.334

0.001

Summer (n = 486)

25(OH)D3

0.943(0.895, 0.994)

4.688

0.030

0.901(0.850,0.956)

12.117

< 0.001

F-25(OH)D

0.809(0.666, 0.983)

4.570

0.033

0.786(0.646,0.956)

5.777

0.016

Autumn (n = 240)

25(OH)D3

0.919(0.860,0.981)

6.399

0.011

0.735(0.640,0.845)

18.916

< 0.001

F-25(OH)D

NA

NA

NA

NA

NA

NA

Winter (n = 230)

25(OH)D3

NA

NA

NA

NA

NA

NA

F-25(OH)D

NA

NA

NA

NA

NA

NA

  1. Significant values are given in bold.
  2. *Relative to the mild CKD group. Stepwise logistic regression was used, and adjusted factors included age, gender, season, hsCRP, and RF. “NA” means the variable is excluded from regression analysis because P > 0.1.
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