Table 3 Adverse event profiles.
Adverse Effect | Overall (%) | Before matching | After matching | ||||
|---|---|---|---|---|---|---|---|
Nimotuzumab 59 | No- Nimotuzumab 144 | P value | Nimotuzumab 54 | No- Nimotuzumab 54 | P value | ||
Hematologic | 166(94.3) | 50(90.9) | 116(95.9) | 0.744 | 45(91.8) | 48(96.0) | 0.439 |
G3-4 | 83(47.1) | 26(47.3) | 57(47.1) | 0.984 | 26(53.1) | 20(40) | 0.193 |
Neutropenia | 134(76.1) | 36(65.5) | 98(81.0) | 0.106 | 31(63.3) | 38(76.0) | 0.281 |
G3-4 | 45(25.6) | 12(21.8) | 33(27.3) | 0.442 | 12(24.4) | 10(20) | 0.591 |
Thrombocytopenia | 79(45.1) | 22(40.0) | 57(47.5) | 0.487 | 17(34.7) | 22(44.0) | 0.195 |
G3-4 | 15(8.5) | 6(10.9) | 9(7.4) | 0.445 | 6(12.2) | 3(6.0) | 0.280 |
Anemia | 139(79) | 41(74.5) | 98(81.0) | 0.302 | 39(79.6) | 39(78.0) | 0.090 |
G3-4 | 43(24.4) | 17(30.9) | 26(21.5) | 0.178 | 17(34.7) | 8(16.0) | 0.032 |
Nonhematologic | |||||||
Radiation proctitis | 64(36) | 26 (46.4) | 38(31.1) | 0.306 | 21 (42.0) | 15(30.0) | 0.363 |
G3-4 | 3(1.7) | 1(1.8) | 2(1.6) | 0.944 | 1(2.0) | 1(2.0) | 1.000 |
Nausea/vomiting | 63(35.8) | 19 (34.5) | 44 (35.4) | 0.845 | 14 (28.6) | 19 (38.0) | 0.460 |
G3-4 | 3(1.7) | 0(0) | 3(2.5) | 0.239 | 0(0) | 2(4.0) | 0.157 |
Radiation cystitis | 15(8.5) | 4(7.3) | 11 (9.1) | 0.773 | 4(8.2) | 5 (12) | 0.526 |
G3-4 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
Fatigue | 57 (32.4) | 22 (40.0) | 35 (28.9) | 0.205 | 17 (34.7) | 13 (26.0) | 0.438 |
G3-4 | 2 (1.1) | 0 (0) | 2 (1.7) | 0.338 | 0 (0) | 1 (2.0) | 0.320 |
