Table 2 Prediction of genes related to probiotics.

From: Unveiling the probiotic potential of the genus Geobacillus through comparative genomics and in silico analysis

Function

Genes

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

Modulation of the immune system/Acid stress

clpB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

cysS

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

cysE

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

P

cysK

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

P

P

nrdD

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

P

P

nrdR

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

nrdH

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

N

P

nrd E

P

P

P

P

P

P

P

P

P

P

N

N

P

P

N

P

P

P

P

P

P

N

P

nrdB

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

P

P

P

N

N

N

N

P

nrdF

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

P

P

pyrC

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

pyrE

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

pyrH

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

pyrR

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

pyrP

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

pyrB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

pyrG

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

pyrK

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

P

pyrF

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

pyrDB

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

trxA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

trxB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

yjbK

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

P

yjbM

N

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

dltC

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

Adhesion

srtA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

srtC

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

srtD

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

fbpA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

lpsA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

dltD

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

dltA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

ClpB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

ClpX

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

ClpS

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

ClpC

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

strA1

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

strA2

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

strA3

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

tuf

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

lapA

N

P

N

N

P

N

N

N

N

N

P

N

N

P

N

P

P

P

N

N

N

N

N

PilA

N

N

N

P

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

PilB

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

PilT

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

PilC

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

PilM

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

PilN

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

PilO

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

PilZ

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

comC

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

N

Bacterial colonization

TadA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

TadB

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

TadC

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

TadE

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

TadF

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

TadZ

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

Acid stress

atpC

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

p

P

atpD

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

atpG

P

P

P

P

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

P

atpH

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

P

P

atpF

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

atpB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

atpE

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

recA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

sodA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

P

relA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

aspS

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

cspA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

P

N

Acid stress/bile resistance

gpmA

N

N

N

P

P

P

P

N

N

N

P

P

P

N

P

N

N

N

P

P

P

P

P

gpml

N

P

N

N

P

P

P

P

P

P

P

P

P

P

P

N

P

P

N

N

N

N

N

glmU

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

glmS

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

glmM1

P

P

P

P

P

N

N

N

N

P

P

P

P

P

P

P

P

P

P

P

P

P

P

glmM2

P

P

P

P

P

N

N

N

N

P

P

P

P

P

P

P

P

P

P

P

P

P

P

bshA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

bshB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

bshC

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

luxS

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

Bile resistance

nagB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

pyrG

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

argS

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

rpsC

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

rpsE

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

rplD

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

rplE

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

rplF

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

Osmotic stress

opuA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

opuC

N

N

N

N

N

P

P

P

N

P

P

P

P

N

N

N

N

N

N

N

N

N

N

opuD

P

N

P

N

P

P

P

P

P

N

N

N

N

N

N

P

P

N

N

N

N

N

N

opuB

N

N

N

N

N

N

N

N

P

N

N

N

P

N

N

N

N

N

N

N

N

N

N

opuCA

P

P

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

N

N

P

N

N

oupCB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

N

opuCC

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

N

Molecular chaperones

groES

N

N

N

P

N

N

N

N

N

N

N

N

N

N

P

N

P

N

N

N

N

N

N

groEL

N

N

N

P

N

N

N

N

N

N

N

N

N

N

P

P

P

N

N

N

N

N

N

dnaK

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

dnaJ

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

dnaG

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

Fatty acid synthesis

fabD

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

P

fabH

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

P

fabF

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

P

fabL

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

fabZ

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

P

accC

N

P

N

N

P

N

N

N

P

P

P

P

N

P

P

P

P

P

N

N

P

N

P

Lactate synthesis

mdh

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

Others

dapA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

 

dps

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

Transcriptional regulator

sigB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

N

N

N

 

sigX

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

N

N

N

 

ctsR

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

N

 

hrcA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

Metabolic rearrangement

alsD

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

N

Vitamin biosynthesis

copA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

copZ

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

P

P

N

N

N

P

N

copZA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

csoR

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

BtuF

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

BtuC

N

N

N

P

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

BtuD

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

Oxidative stress

trxA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

trxB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

feoB

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

N

P

oxyR

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

N

N

N

N

N

N

N

cydA

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

cydC

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

yocS

N

N

N

P

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

N

N

gpx

N

N

P

P

N

N

N

P

N

N

N

P

N

N

P

N

N

N

N

N

N

N

N

ndh

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

ndhF

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

N

N

ndhS

P

P

N

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

ndhB

P

N

P

N

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

N

ndhC

P

P

P

P

P

P

N

P

P

P

P

P

P

P

P

P

P

P

N

N

N

N

N

ndhH

P

P

P

P

P

N

N

N

N

N

N

N

N

P

P

P

P

P

N

N

N

N

N

ndhD

N

N

N

P

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

msrA

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

P

P

P

msrB

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

msrC

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

P

N

N

P

P

P

CRISPR-Cas

Cmr1

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

Cmr2

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

N

Cmr3

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

Cmr4

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

Cmr5

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

Cmr6

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

TM1812

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

Csd1

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

Csd2

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

Cas5h

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

Cas3

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

Cas4

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

P

N

N

N

N

N

N

Cas1

P

N

P

N

N

P

P

P

N

N

P

P

P

N

N

P

P

P

N

N

N

N

N

Cas2

P

N

P

N

N

P

P

P

P

N

P

P

P

N

N

P

P

P

N

N

N

N

N

Cas6

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

P

N

N

N

N

N

N

cas9

P

P

N

N

N

N

P

N

N

N

N

P

N

N

N

N

N

P

N

N

N

N

N

cas10

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

N

N

csx1

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

csm6

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

P

N

N

N

N

N

N

N

cst1

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

DevR

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

N

P

N

N

N

N

N

N

  1. A = G. icigianus, B = G. thermoleovorans, C = G. uzenensis, D = G. vulcani, E = G. zalihae, F = G. lituanicus, G = G. stearothermophilus, H = G. subterraneus, I = G. thermodenitrificans, J = G. kaustophilus, K = G. proteiniphilus, L = G. jurassicus, M = G. thermocatenulatus, N = G. sp. CAMR5420, O = G. sp. GHH01, P = G. sp. Y412MC52, Q = G. sp. C56-T3, R = G. sp. LEMMJ02, S = B. breve, T = B. longum, U = L. plantarum, V = L. acidophilus, W = L. delbrueckii.
  2. P = Positive/Present, N = Negative/Not Present.
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