Fig. 3 | Scientific Reports

Fig. 3

From: Direct cell interactions potentially regulate transcriptional programmes that control the responses of high grade serous ovarian cancer patients to therapy

Fig. 3

Functional annotation and transcription factor activity a. Functional annotation of DEG when comparing doublets of different clinical outcomes b. Transcription factor (TF) activity across singlets and doublets showing clustering by clinical outcomes c-e. Differential TF activities in doublets for (c) complete remission compared to progressive disease (d) partial remission compared to progressive disease (e) complete remission compared to partial remission. Differential gene expression was initially performed for the compared cancer-stromal doublet groups and TF activities were inferred from the significantly differentially expressed genes.

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