Fig. 5 | Scientific Reports

Fig. 5

From: Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease

Fig. 5

F3-4 MASLD fibrosis groups have significantly higher fibrosis heterogeneity than F1-2. (A) IQR is calculated for each fibrosis group and indicates a larger distribution of CPV values in F3-4. (B) Obtained values from CV analysis per sample is used to determine the cut-off values. The variation degree of each sample in F1-2 and F3-4 is stated according to the cut-off values. (C) Cut-off values are determined from the AUROC for CPA and CPV based on the Youden index. (D) IQR is calculated for each group and indicates a larger distribution of EPV values in F3-4. (E) Obtained values from CV analysis per sample are used to determine the cut-off values of EPV. The variation degree of each sample in F1-2 and F3-4 is stated according to the EPV cut-off values. (F) Cut-off values are determined from the AUROC for EPV based on the Youden index. (G and H) The 3D histogram analysis executed in MATLAB shows the percentage of slices based on CPV and EPV cut-off values in fibrosis stages. CV: Coefficient of variation; IQR: interquartile range; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Int: intermediate.

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