Fig. 5
From: Suppressed DNA repair capacity in flight attendants after air travel
Repair activity of DNA glycosylase-based lesion repair in nine FA. (a) DNA glycosylase-dependent initiation of BER was measured for uracil (U:G)-, hypoxanthine (Hx:T)-, 8oxoG:C-, and A:8oxoG lesions. For these assays, the unrepaired DNA lesion results in a transcriptional error that leads to fluorescent reporter expression. Consequently, reporter expression is inversely proportional to repair capacity. % Reporter expression is plotted on the y-axis versus the flight status (before flight, BF, maroon bar) or (after flight, AF, blue bar) on x-axis. Each symbol represents a single FM-HCR measurement from one FA. Error bars represent mean ± SD. Asterisks indicate p ≤ 0.05 by two-tailed paired t-test. (b) Data from panel A are replotted with a connecting line between triangle symbols to indicate data from the same individual before (BF, maroon upward facing triangle) and after flight (AF, blue downward facing triangle).
