Table 2 The heterogeneity analysis by Cochran’s Q test and horizontal Pleiotropy analysis by MR-Egger regression.

From: Causal association between endocrine diseases and lymphoid malignancies explored through two-sample Mendelian randomization analysis

Outcome

Exposure

Heterogeneity (IVW)

Pleiotropy

Q

Q_pval

MR-Egger Intercept

P value

DLBCL

T2D

103.58

0.73

-0.0014

0.9

 

Obesity

4.19

0.76

-0.0117

0.85

 

dHypo

7.39

0.19

0.048

0.37

 

HPL

19.81

0.14

-0.0248

0.56

 

HTH

12.81

0.17

-0.126

0.05

LL

T2D

125.86

0.18

0

0.08

 

Obesity

1.67

0.95

0.0001

0.65

 

dHypo

10.43

0.11

-0.0002

0.11

 

HPL

9.39

0.81

0

0.94

 

HTH

7.34

0.6

0

0.31

FL

T2D

103.25

0.76

-0.0161

0.35

 

Obesity

4.7

0.58

0.1195

0.36

 

dHypo

6.78

0.24

0.142

0.1

 

HPL

11.43

0.57

0.0032

0.95

 

HTH

17.49

0.06

0.036

0.67

NHL

T2D

132.42

0.11

0.0018

0.82

 

Obesity

8.01

0.24

0.0667

0.31

 

dHypo

12.36

0.05

-0.0054

0.9

 

HPL

7.3

0.92

0.029

0.21

 

HTH

77.53

0

-0.164

0.1

Lymph node tumor

T2D

135.56

0.08

0.0029

0.82

 

Obesity

7.53

0.27

-0.0388

0.7

 

dHypo

3.51

0.62

-0.0161

0.73

 

HPL

11.61

0.56

-0.0082

0.81

 

HTH

5.53

0.9

-0.0258

0.52

  1. IVW, inverse variance weighted; DLBCL, Diffuse Large B-Cell Lymphoma; LL, Lymphocytic Leukemia; FL, Follicular Lymphoma; NHL, Non-Hodgkin’s Lymphoma; T2D, type 2 diabetes; dHypo, diabetic hypoglycemia; HPL, hyperlipidemia; HTH, hyperthyroidism.
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