Fig. 7 | Scientific Reports

Fig. 7

From: Integrative bioinformatics and machine learning identify key crosstalk genes and immune interactions in head and neck cancer and Hodgkin lymphoma

Fig. 7

Network analysis of hub genes with MFs and their correlation with drug sensitivity. (a) Interaction network of TFs and hub genes IL6, CXCL13, and PLAU, showing the regulatory relationships among them. (b) Refined network showing key TFs such as STAT3, CREB1, and GATA2 with strong interactions regulating the hub genes. (c) Heatmap displaying the correlation between hub gene expression and MFs, where darker colors indicate stronger correlations. (d) Correlation between hub gene expression and GDSC drug sensitivity. CXCL13 shows a negative correlation with sensitivity to several drugs, while PLAU and IL6 have mixed effects. (e) Correlation between hub gene expression and drug sensitivity in the CTRP dataset, revealing that IL6 and PLAU are positively correlated with resistance to several drugs.

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