Fig. 4

ROC curve analysis for cell-free CP mRNA level in distinguishing HCC from non-HCC conditions. The ROC curves illustrate the diagnostic performance of CP mRNA in three comparisons: (A) HCC vs. chronic liver disease (AUC = 0.704, sensitivity = 50.98%, specificity = 95.24%, cutoff = 3.24); (B) HCC vs. healthy controls (AUC = 0.812, sensitivity = 74.51%, specificity = 80.65%, cutoff = 0.28), and (C) HCC vs. the combined control group (AUC = 0.768, sensitivity = 50.98%, specificity = 96.15%, cutoff = 3.24).