Table 5 Analysis of HIF1A gene polymorphisms and IS susceptibility.
From: The association of HIF1A gene polymorphism and its expression with ischemic stroke
SNPs | Model | Genetic typing | Physical examination group | The IS group | OR (95% CI) | P | P´ |
|---|---|---|---|---|---|---|---|
rs10873142 | Codominant model | TT | 93 | 83 | Ref | ||
CT | 42 | 66 | 0.535(0.187–1.537) | 0.246 | > 1 | ||
CC | 6 | 10 | 0.915(0.319–2.786) | 0.915 | > 1 | ||
The dominant model | CC | 93 | 83 | Ref | |||
CT + TT | 48 | 76 | 1.774(1.112–2.830) | 0.016 | 0.096 | ||
Recessive model | CT + CC | 135 | 149 | Ref | |||
TT | 6 | 10 | 1.510(0.535–4.266) | 0.437 | > 1 | ||
Overdominant model | CC + TT | 99 | 93 | Ref | |||
CT | 42 | 66 | 1.143(0.711–1.837) | 0.580 | > 1 | ||
allele model | T | 228 | 232 | Ref | |||
C | 54 | 86 | 1.565(1.064–2.303) | 0.023 | 0.138 | ||
rs11549465 | Codominant model | CC | 125 | 147 | Ref | ||
CT | 15 | 11 | 1.176(0.909–18.995) | 0.909 | > 1 | ||
TT | 1 | 1 | 0.733(0.041–13.050) | 0.833 | > 1 | ||
The dominant model | CC | 125 | 147 | Ref | |||
CT + TT | 16 | 12 | 0.638(0.291–1.399) | 0.262 | > 1 | ||
Recessive model | CT + CC | 140 | 158 | Ref | |||
TT | 1 | 1 | 0.886(0.055–14.299) | 0.932 | > 1 | ||
Overdominant model | CC + TT | 126 | 148 | Ref | |||
CT | 15 | 11 | 0.624(0.277–1.408) | 0.624 | > 1 | ||
allele model | C | 265 | 305 | Ref | |||
T | 17 | 13 | 0.664(0.317–1.393) | 0.279 | > 1 | ||
rs11549467 | Codominant model | GG | 135 | 153 | Ref | ||
AG | 6 | 6 | 0.898(0.556–1.449) | 0.659 | > 1 | ||
allele model | G | 276 | 312 | Ref | |||
A | 6 | 6 | 0.885(0.282–2.775) | 0.834 | > 1 |
