Table 3 Lung diffusion capacity (DL) – DLCO and DLNO - for all patients and for subgroups. Data are presented as mean ± sd, p-value for comparison to ‘no findings’.

From: Carbon monoxide and nitric oxide diffusion capacity of formerly exposed asbestos workers with high-resolution computed tomography in a cross-sectional study

DL

Overall n = 371

Groups

No findings n = 82

Only pleural findings n = 97

Asbestosis score 2–3 with and without pleural findings n = 17

Asbestosis score ≥ 4 with and without pleural findings n = 22

Only emphysema n = 40

Mixed findings n = 113

Mean (SD)

Mean (SD)

Mean (SD)

p-value

Mean (SD)

p-value

Mean (SD)

p-value

Mean (SD)

p-value

Mean (SD)

p-value

DLCO [mmol min− 1 kPa− 1]

7.46 (1.93)

8.44 (1.96)

7.74 (1.71)

0.05

7.75 (1.81)

0.52

6.04 (1.27)

< 0.001

7.10 (0.34)

< 0.001

6.86 (1.74)

< 0.001

DLCO [%LLN]

115.76 (26.03)

122.72 (25.18)

124.17 (22.82)

0.99

119.04 (24.00)

0.98

102.70 (18.50)

0.004

104.76 (29.62)

0.001

109.42 (25.93)

0.001

DLCO [%pred]

85.14 (19.11)

90.98 (18.47)

90.92 (16.80)

0.98

87.34 (17.42)

0.70

74.85 (13.34)

< 0.001

77.63 (21.91)

< 0.001

80.27 (18.83)

< 0.001

DLCO/VA [mmol min− 1 kPa− 1]

1.22 (0.28)

1.29 (0.28)

1.27 (0.25)

1.00

1.22 (0.19)

0.82

1.16 (0.32)

0.21

1.08 (0.29)

< 0.001

1.16 (0.27)

0.01

DLCO/VA [%LLN]

122.98 (27.97)

127.60 (28.07)

130.51 (24.42)

0.94

124.50 (21.91)

0.99

120.19 (33.44)

0.72

106.65 (27.54)

< 0.001

119.26 (28.15)

0.15

DLCO/VA [%pred]

89.07 (20.22)

93.25 (20.34)

94.14 (17.73)

1.00

89.96 (15.36)

0.97

86.27 (23.94)

0.48

78.00 (20.30)

< 0.001

86.02 (20.17)

0.05

DLNO [mmol min− 1 kPa− 1]

27.33 (8.20)

32.00 (6.98)

28.32 (7.59)

0.007

27.14 (6.83)

0.08

20.20 (5.50)

< 0.001

25.64 (9.32)

< 0.001

25.10 (7.87)

< 0.001

DLNO [%LLN]

104.43 (29.81)

109.45 (24.28)

114.49 (27.46)

0.70

102.52 (25.24)

0.86

89.10 (25.06)

0.02

87.29 (29.19)

< 0.001

101.51 (33.15)

0.23

DLNO [%pred]

73.02 (19.81)

79.11 (15.71)

78.81 (18.35)

0.92

72.34 (17.36)

0.33

59.56 (15.10)

< 0.001

63.32 (21.17)

< 0.001

69.79 (21.23)

0.002

DLNO/VA [mmol min− 1 kPa− 1]

15.46 (3.35)

16.87 (2.98)

16.21 (3.15)

0.51

15.30 (2.53)

0.24

13.66 (2.38)

< 0.001

13.92 (3.77)

< 0.001

14.70 (3.34)

< 0.001

DLNO/VA [%LLN]

109.82 (24.91)

112.48 (21.74)

118.47 (22.65)

0.35

111.02 (25.03)

0.99

103.71 (20.25)

0.44

91.99 (23.74)

< 0.001

107.78 (26.76)

0.57

DLNO/VA [%pred]

85.03 (18.61)

88.41 (16.30)

91.19 (17.05)

0.51

85.62 (17.81)

0.56

79.07 (14.35)

0.11

72.42 (18.69)

< 0.001

82.85 (19.68)

0.002

VA [liter]

5.26 (0.95)

5.68 (0.76)

5.23 (0.86)

0.005

5.31 (0.87)

0.43

4.43 (0.93)

< 0.001

5.44 (0.99)

0.54

5.06 (1.00)

< 0.001

VA [%LLN]

105.68 (15.83)

110.69 (10.59)

107.01 (14.02)

0.40

105.48 (17.94)

0.63

93.19 (18.3)

< 0.001

107.03 (16.92)

0.65

102.88 (17.70)

0.003

VA [%pred]

85.11 (12.80)

89.30 (8.53)

86.09 (11.31)

0.32

84.92 (14.50)

0.59

74.9 (14.71)

< 0.001

86.30 (13.65)

0.65

82.79 (14.27)

0.002

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