Table 3 Relative intensities of metabolomics data of controls group and patients group.
Parameter | Controls group | Patients group | p-value | ||
|---|---|---|---|---|---|
Mean± | Median (IQR) | Mean± | Median (IQR) | ||
Cholesterol | 36.5 ± 8.669 | 36.4 (34.23–39.01) | 24.86 ± 10.58 | 24.14 (16.64–30.74) | 0.00 |
Lipids | 50.34 ± 5.75 | 50.32 (47.6–53.0) | 36.9 ± 9.491 | 37.32 (27-42.56) | 0.00 |
Leucine | 27.12 ± 5.446 | 27.86 (22.1–31.2) | 22.38 ± 5.73 | 22.7 (18.44–25.62) | 0.00 |
Isoleucine | 25.58 ± 4.878 | 26.2 (21.78–29.02) | 21.76 ± 9.816 | 20.57 (17.25–23.51) | 0.01 |
Valine | 27.55 ± 5.288 | 28.2 (23.99–30.4) | 22.24 ± 6.915 | 21.81 (18.72–25.2) | 0.00 |
Hydroxybutyrate | 78.19 ± 11.34 | 79.12 (72.2–85.9) | 69.25 ± 22.75 | 69.8 (59.13–87.91) | 0.01 |
Lactate | 19.22 ± 4.967 | 19.57 (14.6–23.5) | 21.69 ± 5.524 | 22.1 (19.1-23.83) | 0.01 |
Alanine | 24.11 ± 5.457 | 23.34 (19.7–28.7) | 22.62 ± 5.217 | 22.62 (20.14–24.69) | 0.14 |
Adipic_acid | 23.98 ± 5.047 | 23.69 (19.75–28.48) | 18.45 ± 4.738 | 18.59 (16.04–20.1) | 0.00 |
Arginine | 15.74 ± 3.628 | 15 (12.77–18.87) | 15.07 ± 6.906 | 14.26 (11.53–16.13) | 0.52 |
Lysine | 14.24 ± 3.119 | 13.79 (11.83–16.63) | 14.17 ± 4.568 | 13.56 (11.13–15.63) | 0.92 |
Acetate | 13.56 ± 2.635 | 13.6 (11.73–15.5) | 28.26 ± 7.154 | 28.64 (23.09–31.43) | 0.00 |
Glutamate | 30.57 ± 3.98 | 30.81 (28.43–33.18) | 24.57 ± 8.129 | 24.95 (19.75–28.28) | 0.00 |
Glutamine | 18.27 ± 2.972 | 18.23 (16.53–19.95) | 14.32 ± 4.841 | 14 (12.17–15.6) | 0.00 |
Ketoglutarate | 12.39 ± 2.239 | 12.19 (10.95–13.68) | 7.976 ± 4.138 | 7.85 (5.37–9.61) | 0.00 |
Citrate | 5.96 ± 1.94 | 5.9 (5.6–6.3) | 7.241 ± 2.915 | 7 (4.558–8.835) | 0.01 |
Albumin | 5.834 ± 1.361 | 5.8 (5.048–6.33) | 6.808 ± 3.804 | 6.4 (4.568–7.803) | 0.08 |
Creatine | 6.35 ± 1.973 | 6.2 (5.625–6.885) | 13.48 ± 5.312 | 12.98 (10.41–15.23) | 0.00 |
Choline | 5.322 ± 2.55 | 5.35 (3.978–6.475) | 5.306 ± 5.665 | 4.57 (1.67–8.108) | 0.99 |
Glucose | 6.384 ± 2.208 | 6.2 (5.6-7) | 9.52 ± 4.705 | 9.305 (7.133–11.48) | 0.00 |
TMAO | 11.61 ± 3.14 | 11.35 (9.95–12.95) | 10.79 ± 4.829 | 10.75 (7.8-13.02) | 0.29 |
Proline | 12.69 ± 3.379 | 12.26 (10.73–14.18) | 12.27 ± 5.257 | 12.29 (8.828–14.44) | 0.61 |
Glycine | 14.45 ± 3.484 | 14.15 (12.88–15.58) | 14.33 ± 4.721 | 14.35 (11.21–16.09) | 0.87 |
Glycerolipids | 14.67 ± 3.48 | 14.25 (13-15.88) | 17.8 ± 5.33 | 17.36 (14.05–19.21) | 0.00 |
Myoinositol | 15.3 ± 3.98 | 14.9 (12.28–18.16) | 14.93 ± 4.864 | 14.75 (11.58–17.01) | 0.66 |
Citruline | 21.73 ± 4.804 | 20.53 (18.17–25.65) | 14.98 ± 4.381 | 14.85 (12.31–17.23) | 0.00 |
Ornithine | 14.05 ± 3.586 | 14.39 (11.18–16.66) | 12.17 ± 4.872 | 12.13 (9.75–13.6) | 0.02 |
Methionine | 11.58 ± 2.59 | 11.8 (10.03–12.78) | 9.007 ± 5.284 | 8.8 (6.633–11.14) | 0.00 |
Glycoproteins | 12.56 ± 2.604 | 12.65 (11.13–13.78) | 7.84 ± 4.799 | 7.235 (5.918–9.94) | 0.00 |
Serine | 8.478 ± 2.869 | 8.45 (7.1-9.675) | 7.458 ± 5.319 | 6.7 (4.4–9.43) | 0.21 |
Creatinine | 6.585 ± 3.19 | 6.48 (4.57–7.758) | 17.66 ± 3.35 | 17.73 (16.1–19.3) | 0.99 |
Threonine | 4.448 ± 2.176 | 4.3 (3.725–5.075) | 3.247 ± 3.504 | 2.655 (0.89–4.8) | 0.00 |
B_glucose | 3.526 ± 2.03 | 3.45 (3.025-3.8) | 1.678 ± 3.525 | 0.61 (0.275–0.95) | 0.00 |
Pyrovate | 2.651 ± 1.679 | 2.6 (2.1-3) | 4.648 ± 5.71 | 2.39 (− 1.118–6.775) | 0.01 |
Glycerol | 2.738 ± 1.068 | 2.65 (2.3-3) | 11.89 ± 22.36 | 3.62 (0.922–10.33) | 0.00 |
Alpha_glucose | 2.187 ± 1.135 | 2 (1.7–2.6) | 4.836 ± 5.024 | 1.905 (0.55–9.54) | 0.00 |
Tyrosine | 6.392 ± 1.405 | 6.375 (6.21–6.59) | 4.823 ± 1.827 | 4.86 (3.878–6.19) | 0.00 |
Histidine | 1.934 ± 0.6319 | 1.89 (1.795–2.008) | 1.927 ± 1.047 | 1.77 (1.25–2.553) | 0.96 |
Tryptophan | 1.285 ± 0.5172 | 1.185 (1.11–1.26) | 1.616 ± 0.924 | 1.515 (1-2.11) | 0.96 |
Methy_histidine | 0.67 ± 0.51 | 0.48 (0.44–0.58) | 1.155 ± 0.740 | 1.13 (0.52–1.618) | 0.00 |
Formate | 0.21 ± 0.18 | 0.15 (0.11–0.25) | 0.5275 ± 0.34 | 0.46 (0.23–0.79) | 0.00 |
