Table 4 Relative intensities of metabolomics data of AML groups (pre- treatment and post-treatment).
Parameter | AML group (pre-treatment) | AML group (post-treatment) | p-value | ||
|---|---|---|---|---|---|
Mean ± S.D | Median (IQR) | Mean ± S.D | Median (IQR) | ||
Cholesterol | 24.86 ± 10.58 | 24.14 (16.64–30.74) | 21.42 ± 13.54 | 20.7 (14.13–26.2) | 0.170 |
Lipids | 36.9 ± 9.491 | 37.32 (27-42.56) | 38.03 ± 16.15 | 39.4 (33.35–44.83) | 0.682 |
Leucine | 22.38 ± 5.73 | 22.7 (18.44–25.62) | 23.58 ± 12.88 | 23.3 (17.74–25.62) | 0.893 |
Isoleucine | 21.76 ± 9.816 | 20.57 (17.25–23.51) | 21.31 ± 11.81 | 20.8 (16.71–25.08) | 0.840 |
Valine | 22.24 ± 6.915 | 21.81 (18.72–25.2) | 20.34 ± 8.804 | 20.3 (17.37–26.58) | 0.244 |
Hydroxybutyrate | 69.25 ± 22.75 | 69.8 (59.13–87.91) | 70.55 ± 27.36 | 72 (57.44–93.83) | 0.801 |
Lactate | 21.69 ± 5.524 | 22.1 (19.1-23.83) | 21.8 ± 10.44 | 22.15 (18.04–26.47) | 0.948 |
Alanine | 22.62 ± 5.217 | 22.62 (20.14–24.69) | 21.02 ± 9.637 | 20.77 (17.9-26.74) | 0.292 |
Adipic_acid | 18.45 ± 4.738 | 18.59 (16.04–20.1) | 22.7 ± 10.57 | 22.85 (17.91–26.96) | 0.016 |
Arginine | 15.07 ± 6.906 | 14.26 (11.53–16.13) | 16.65 ± 8.54 | 16.3 (13.22–19.26) | 0.322 |
Lysine | 14.17 ± 4.568 | 13.56 (11.13–15.63) | 15.05 ± 8.199 | 15 (10.89–16.4) | 0.526 |
Acetate | 28.26 ± 7.154 | 28.64 (23.09–31.43) | 14.11 ± 7.015 | 13.73 (10.51–15.77) | 0.000 |
Glutamate | 24.57 ± 8.129 | 24.95 (19.75–28.28) | 26.32 ± 10.29 | 26.8 (21.35–31.05) | 0.359 |
Glutamine | 14.32 ± 4.841 | 14 (12.17–15.6) | 16.77 ± 9.874 | 16.2 (12.66–17.7) | 0.137 |
Ketoglutarate | 7.976 ± 4.138 | 7.85 (5.37–9.61) | 15.82 ± 8.458 | 15.7 (12.6–16.7) | 0.000 |
Citrate | 7.241 ± 2.915 | 7 (4.558–8.835) | 13.5 ± 6.81 | 13.2 (9.518–14.22) | 0.000 |
Albumin | 6.808 ± 3.804 | 6.4 (4.568–7.803) | 13.08 ± 6.793 | 12.95 (8.65–14.45) | 0.000 |
Creatine | 13.48 ± 5.312 | 12.98 (10.41–15.23) | 9.292 ± 5.962 | 9.15 (5.933–11.48) | 0.000 |
Choline | 5.306 ± 5.665 | 4.57 (1.67–8.108) | 16.85 ± 9.135 | 16.5 (12.39–17.48) | 0.000 |
Glucose | 9.52 ± 4.705 | 9.305 (7.133–11.48) | 8.348 ± 4.509 | 8.2 (6.7–9.9) | 0.209 |
TMAO | 10.79 ± 4.829 | 10.75 (7.8-13.02) | 8.586 ± 5.21 | 8.55 (6.825–10.1) | 0.033 |
Proline | 12.27 ± 5.257 | 12.29 (8.828–14.44) | 14.74 ± 6.753 | 14.9 (13.6–16.2) | 0.042 |
Glycine | 14.33 ± 4.721 | 14.35 (11.21–16.09) | 9.793 ± 5.829 | 9.69 (5.42–12.6) | 0.000 |
Glycerol | 17.8 ± 5.33 | 17.36 (14.05–19.21) | 11.76 ± 5.3 | 11.65 (8.173–14.81) | 0.000 |
Myoinositol | 14.93 ± 4.864 | 14.75 (11.58–17.01) | 13.3 ± 5.2 | 13.5 (9.4–15.9) | 0.135 |
Citruline | 14.98 ± 4.381 | 14.85 (12.31–17.23) | 15.38 ± 5.844 | 15.3 (12.76–17.73) | 0.705 |
Ornithine | 12.17 ± 4.872 | 12.13 (9.75–13.6) | 15.65 ± 6.148 | 15.5 (12.76–17.85) | 0.003 |
Methionine | 9.007 ± 5.284 | 8.8 (6.633–11.14) | 16.59 ± 5.46 | 16.3 (13.83–17.57) | 0.000 |
Glycoproteins | 7.84 ± 4.799 | 7.235 (5.918–9.94) | 20.57 ± 8.454 | 20.13 (16.2–21.4) | 0.000 |
Serine | 7.458 ± 5.319 | 6.7 (4.4–9.43) | 19.2 ± 9.292 | 18.85 (14.5–20.0) | 0.000 |
Creatinine | 17.66 ± 3.35 | 17.73 (16.1–19.3) | 8.509 ± 3.929 | 8.15 (6.73–9.303) | 0.000 |
Threonine | 3.247 ± 3.504 | 2.655 (0.89–4.8) | 18.16 ± 10.54 | 17.65 (13.7–18.8) | 0.000 |
B_Glucose | 1.678 ± 3.525 | 0.61 (0.275–0.95) | 16.5 ± 12.11 | 15.95 (11.5–17.1) | 0.000 |
Pyrovate | 4.648 ± 5.71 | 2.39 (− 1.118–6.775) | 14.09 ± 12.91 | 13.74 (6.11–14.68) | 0.036 |
Glycerol_Lipids | 11.89 ± 22.36 | 3.62 (0.922–10.33) | 12.84 ± 12.91 | 12.27 (5.56–13.5) | 0.790 |
Alpha_Glucose | 4.836 ± 5.024 | 1.905 (0.55–9.54) | 12.55 ± 13.97 | 12.05 (4.3–13.1) | 0.001 |
Tyrosine | 4.823 ± 1.827 | 4.86 (3.878–6.19) | 5.323 ± 4.751 | 3.425 (2.15–7.943) | 0.010 |
Histidine | 1.927 ± 1.047 | 1.77 (1.25–2.553) | 2.486 ± 2.626 | 1.595 (0.52–3.45) | 0.470 |
Tryptophan | 1.616 ± 0.924 | 1.515 (1–2.11) | 1.864 ± 2.148 | 1.025 (0.38–2.87) | 0.304 |
Methyl_histidine | 1.155 ± 0.740 | 1.13 (0.52–1.618) | 1.03 ± 1.111 | 0.645 (0.20–1.56) | 0.101 |
Formate | 0.5275 ± 0.34 | 0.46 (0.23–0.79) | 0.648 ± 0.6131 | 0.5 (0.25–0.88) | 0.895 |
