Fig. 11
Electron micrographs of cerebellar cortex sections from cisplatin treated groups (A–C) and Cis + AG. SeNps. Group (D–F). The cisplatin sections exhibit Purkinje cells with pyknotic nuclei (N), dilatation of the rough endoplasmic reticulum (rer), vacuolated nucleoplasm (red arrow), swollen mitochondria (m), degenerated neuropil (green arrow). Splitting and break down of the myelin sheath result in the appearance of myelinated nerve axons (*) and neural filaments (nf), and the granular layer shows destroyed granulocytes with pyknotic nuclei and an invaginated nuclear envelope (Gc). (Cis + AG. SeNps.) Combined group showed quite intact Purkinje cells with normal nucleus (N), dilated rough endoplasmic reticulum (rer), granulocytes (Gc), normal axons (*). Pre-normal mitochondria (m), neuropil (green arrow) and pre- and post-synapses (blue arrow) while still suffering from apoptosis (A). Scale bar 5 μm, insets 2 µm.
