Table 3 Risk factors for ALN identified by univariate and multivariate logistic regression.
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
OR (95% CI) | P value | OR (95% CI) | P value | |
Quadrant | < 0.001 | |||
Central region | Reference | Reference | ||
Axillary tail | 6.999 (4.192–11.685) | < 0.001 | 4.648 (2.248–9.611) | < 0.001 |
Multiple sites | 3.310 (1.852–5.918) | < 0.001 | 2.629 (1.118–6.183) | 0.027 |
UOQ | 1.495 (1.089–2.054) | < 0.013 | 1.785 (1.121–2.842) | 0.015 |
LOQ | 0.980 (0.573–1.674) | 0.940 | 0.701 (0.314–1.568) | 0.388 |
UIQ | 0.491 (0.294–0.820) | 0.007 | 0.771 (0.369–1.613) | 0.490 |
LIQ | 0.862 (0.521–1.425) | 0.563 | 1.532 (0.748–3.141) | 0.244 |
Histological grade | 0.038 | 0.422 | ||
1 | Reference | Reference | ||
2 | 2.255 (1.147–4.435) | 0.018 | 0.734 (0.277–1.947) | 0.534 |
3 | 2.549 (1.245–5.221) | 0.011 | 0.981 (0.342–2.809) | 0.971 |
Multifocality | < 0.001 | 0.621 | ||
Single | Reference | Reference | ||
Bifocal | 1.445 (0.969–2.155) | 0.071 | 1.122 (0.624–2.019) | 0.700 |
Multifocal | 2.273 (1.643–3.144) | < 0.001 | 1.278 (0.769–2.123) | 0.343 |
Tumor size | < 0.001 | 0.002 | ||
T1 (≤ 2 cm) | Reference | Reference | ||
T2 (2 – 5 cm) | 2.148 (1.656– 2.786) | < 0.001 | 1.594 (1.088–2.334) | 0.017 |
T3 & T4 | 5.817 (3.329–10.162) | < 0.001 | 3.936 (1.745–8.879) | 0.001 |
Molecular subtype | 0.033 | < 0.001 | ||
HR+/HER2- | Reference | Reference | ||
HR+/HER2+ | 1.107 (0.758–1.618) | 0.598 | 0.847 (0.484–1.483) | 0.562 |
HR−/HER2+ | 1.254 (0.786–2.001) | 0.342 | 0.668 (0.314–1.420) | 0.295 |
TNBC | 0.624 (0.436–0.893) | 0.01 | 0.273 (0.154–0.484) | < 0.001 |
LVI | ||||
Negative | Reference | Reference | ||
Positive | 5.608 (4.383–7.175) | < 0.001 | 3.836 (2.713–5.423) | < 0.001 |
Skin involvement | ||||
Negative | Reference | Reference | ||
Positive | 2.038 (1.279–3.248) | 0.003 | 0.954 (0.450–2.021) | 0.902 |
Nipple involvement | ||||
Negative | Reference | Reference | ||
Positive | 2.470 (1.457–4.187) | 0.001 | 1.686 (0.772–3.682) | 0.190 |
Axillary sonography | ||||
Reactive LN | Reference | Reference | ||
Pathological Features | 34.254 (24.80–47.298) | < 0.001 | 27.740 (19.269–39.936) | < 0.001 |
