Abstract
This study aimed to investigate the relationship between myopia and retinal vascular oxygen saturation, after accounting for optical factors and individual variations. This was a prospective, observational, single-center study. Adults with anisometropia were included. All the participants underwent femtosecond-assisted laser in situ keratomileusis (FS-LASIK), and before and after the surgery, all the patients underwent the examination of visual acuity, intraocular pressure (IOP), spherical equivalent (SE), average keratometry (K), central corneal thickness, and retinal oximeter. A total of 196 adult patients with myopic anisometropia were enrolled. The SE of the less myopic eyes before surgery was − 3.89 ± 3.24 D, which was significantly higher than that of the more myopic eyes − 6.75 ± 3.10 D (p < 0.001). The retinal arterial oxygen saturation (SaO2) of the less myopic eyes was 94.08 ± 1.61%, which was significantly higher than that of the more myopic eyes 93.36 ± 1.74% (p = 0.003). After FS-LASIK, the SaO2 of the less myopic eyes (93.29 ± 1.72%) remained significantly higher than that of the more myopic eyes (92.76 ± 1.83%) (p = 0.038). In the multivariate regression analysis, the postoperative SaO2 was still significantly negatively correlated with axial length (AL) (B = -0.252, P = 0.009). After excluding optical factors and individual variations, SaO2 remains negatively correlated with AL. Myopia exerts an optical magnification effect on SaO2.
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The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- AL:
-
Axial length
- AVD:
-
Retinal arteriovenous oxygen saturation difference
- CCT:
-
Central corneal thickness
- CDVA:
-
Corrected distance visual acuity
- FS-LASIK:
-
Femtosecond-assisted laser in situ keratomileusis
- ICL:
-
Implantable collamer lens
- IOP:
-
Intraocular pressure
- K:
-
Average keratometry
- SaO2 :
-
Retinal arterial oxygen saturation
- SE:
-
Spherical equivalent
- SvO2 :
-
Retinal venous oxygen saturation
- UCVA:
-
Uncorrected distance visual acuity
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Shanshan Ge, Xiaoqi Ma, Xiuli Zhou and Yuehua Zhou made substantial contributions to the conception, design of the work, the acquisition, analysis, and interpretation of data. Shanshan Ge drafted the work. Yuehua Zhou revised it critically for important intellectual content. All authors read and approved the final manuscript.
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The Medical Ethics Committee of the Ineye Hospital of Chengdu University of TCM approved this study, and the number was 2021yh-022. The study was in accordance with the Helsinki Declaration of 1964.
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Ge, S., Ma, X., Zhou, X. et al. Changes in retinal oxygen saturation before and after femtosecond LASIK in adult myopic individuals with anisometropia. Sci Rep (2026). https://doi.org/10.1038/s41598-026-37955-4
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DOI: https://doi.org/10.1038/s41598-026-37955-4
