Table 1 Differences in unique antimicrobial resistance genes (ARGs) per antimicrobial resistance class between European and African stools.

From: Gut microbiota and resistome profiles of Swiss expatriates in Africa revealed by Nanopore metagenomics

ARG class

Unique ARGsa

Shared ARGsb

Total ARGs c

p-value d

p-value (adj) e

Unique ARGs f

Europe

Africa

Europe

Africa

Tetracyclines

3

8

29

40

0.2

1

tetA(46)_1_HQ652506, tet(M)_8_X04388, tet(X6)_1_MN507533

tet(O/32/O)_6_NG_048124, tet(O/32/O)_2_AJ295238, tet(O/32/O)_5_FP929050,

tet(M)_2_X90939, tet(M)_10_EU182585, tet(W)_2_AY049983, tetA(P)_2_L20800,

tet(M)_1_X92947

Macrolides and other

3

3

13

19

1

1

msr(C)_2_AF313494, erm(X)_1_M36726, msr(C)_1_AY004350

erm(G)_2_L42817, erm(B)_21_U35228, erm(T)_2_AY894138

Aminoglycosides

7

7

8

22

1

1

aph(2)-Ia_2_AP009486, aph(2)-Ia_3_AJ536195,

aac(6)-Ii_1_L12710, npmA_1_AB261016,

aadA8b_2_AM040708, aadA2_2_JQ364967,

aadA1_4_JQ480156

aadA1_3_JQ414041, aadA1_5_JX185132, ant(6)-Ia_2_KF421157,

aac(6)-Iid_1_AJ584700, aph(2)-Ig_1_CP004067, aph(6)-Id_4_CP000971,

aadA5_1_AF137361

Lincosamides

0

1

2

3

1

1

None

lnu(B)_2_JQ861959

Quinolones

1

2

0

3

1

1

qnrS1_1_AB187515

qepA4_1_KX580704, qnrB19_1_EU432277

Lincosamides

and other

1

1

0

2

1

1

lsa(A)_1_AY225127

lsa(E)_1_JX560992

Ī²-lactams

3

5

8

16

0.7

1

blaTEMāˆ’30_1_AJ437107, blaTEMāˆ’95_1_AJ308558,

blaTEMāˆ’1D_1_AF188200

blaOXAāˆ’1_1_HQ170510, blaACTāˆ’6_1_FJ237366, cepA_1_L13472,

cepA_1_U05887, cfiA14_1_FM200789

Folate pathway antagonists

0

6

3

9

0.2

1

None

dfrA7_1_AB161450, sul2_3_HQ840942, dfrA17_1_FJ460238,

sul2_18_AJ830714, dfrA14_4_AF393510, sul2_6_FN995456

Amphenicols

1

2

3

6

1

1

floR_2_AF118107

catA1_1_V00622, Cfr(E)_1_NG_070225

Nitroimidazoles

0

1

2

3

1

1

None

nimD_1_X76949

Macrolides

2

1

1

4

1

1

mef(A)_1_AJ971089, ere(D)_1_KP265721

mef(A)_2_U83667

Amphenicols

and other

0

0

2

2

1

1

None

None

Glycopeptides

0

3

1

4

0.4

1

None

VanHDX_4_AY082011, VanHDX_5_AY489045, VanG2XY_1_FJ872410

  1. aNumber of unique ARGs found in both European and African samples.
  2. bShared ARGs between both European and African samples.
  3. cTotal count of all ARGs.
  4. dThe p-value of the Fisher exact test result assessing the significance of unique ARGs between European and African samples.
  5. eThe p-value adjusted for multiple testing (FDR corrected).
  6. fThe list of ARG hits from the ResFinder database unique to European and African samples. See Supplementary Data 1 and Supplementary Data 3 for ARGs definition and the complete ARG dataset, respectively.
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