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Prevalence and correlates of postpartum depression during the COVID-19 pandemic: a cross-sectional study in Vietnam
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  • Published: 16 February 2026

Prevalence and correlates of postpartum depression during the COVID-19 pandemic: a cross-sectional study in Vietnam

  • Ha Thu Thi Nguyen1,
  • Hien Thu Nguyen2,3,
  • Thuong Huyen Thi Phan4,
  • Giang Tra Thi Duong1,
  • Linh Anh Do5,
  • Ha Ngoc Vu6,7,
  • Tham Thi Nguyen7,8,
  • Laurent Boyer8,
  • Bastien Boussat9,
  • Pascal Auquier8,
  • Cuong Tat Nguyen2,3,
  • Duc Anh Ha10,
  • Huyen Do5,11,12,
  • Giang Thu Vu5,12,
  • Roger C. M. Ho13,14 &
  • …
  • Cyrus S. H. Ho15 

Scientific Reports , Article number:  (2026) Cite this article

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  • Health care
  • Medical research

Abstract

Postpartum depression (PPD) is a common mental health issue that negatively impacts maternal well-being and infant development. The COVID-19 pandemic has exacerbated depression risk among postpartum women due to added stressors from the crisis. This study aimed to assess PPD prevalence during the pandemic and identify associated factors. The study was conducted at Hanoi Obstetrics and Gynecology Hospital from May 2023 to December 2023. This cross-sectional study selected 223 postpartum women via convenience sampling. Data collection utilized online surveys and phone interviews. The Edinburgh Postnatal Depression Scale (EPDS) gauged depression levels, analyzed using Stata 16.0. Descriptive statistics and logistic regression explored relationships between PPD and contributing factors. Among participants, 22.0% scored 9–11 on EPDS, indicating mild depression; 5.8% were high-risk (EPDS 12–13), and 8.5% had PPD (EPDS > 14). The study identified links between PPD and poor sleep, COVID-19 anxiety, and limited social support. PPD remains a critical concern during COVID-19, with factors like sleep quality, pandemic-related anxiety, and social support influencing depression risk. Early screening and psychological interventions are crucial to mitigate PPD’s impact on maternal and infant health post-pandemic.

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Data availability

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thank the Hanoi Obstetrics and Gynecology Hospital, the National University of Singapore, and the research collaborator.

Funding

There was no funding for this study.

Author information

Authors and Affiliations

  1. National Hospital of Obstetrics and Gynecology (NHOG), Hanoi, 10000, Vietnam

    Ha Thu Thi Nguyen & Giang Tra Thi Duong

  2. Institute for Global Health Innovations, Duy Tan University, Da Nang, 55000, Vietnam

    Hien Thu Nguyen & Cuong Tat Nguyen

  3. Faculty of Nursing, Duy Tan University, Da Nang, 55000, Vietnam

    Hien Thu Nguyen & Cuong Tat Nguyen

  4. Hanoi Obstetrics and Gynecology Hospital, Hanoi, 10000, Vietnam

    Thuong Huyen Thi Phan

  5. College of Health Sciences, VinUniversity, Hanoi, 10000, Vietnam

    Linh Anh Do, Huyen Do & Giang Thu Vu

  6. Faculty of Public Health, VNU University of Medicine and Pharmacy, Vietnam National University (VNU-UMP), Hanoi, 10000, Vietnam

    Ha Ngoc Vu

  7. International Institute for Training and Research (INSTAR), VNU University of Medicine and Pharmacy, Vietnam National University (VNU- UMP), Hanoi, 10000, Vietnam

    Ha Ngoc Vu & Tham Thi Nguyen

  8. CEReSS-Health Service Research and Quality of Life Center, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille University, Marseille, 13005, France

    Tham Thi Nguyen, Laurent Boyer & Pascal Auquier

  9. Department of Clinical Epidemiology, Grenoble Alps University, Grenoble, 38000, France

    Bastien Boussat

  10. Department of Medical Service Administration - Ministry of Health, Hanoi, 10000, Vietnam

    Duc Anh Ha

  11. Department of Health Policy and Management, College of Health Science, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea

    Huyen Do

  12. Institute of Health Economics and Technology (iHEAT), Hanoi, Vietnam

    Huyen Do & Giang Thu Vu

  13. Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, 119077, Singapore

    Roger C. M. Ho

  14. Division of Life Science (LIFS), Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Hong Kong, China

    Roger C. M. Ho

  15. Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore

    Cyrus S. H. Ho

Authors
  1. Ha Thu Thi Nguyen
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  2. Hien Thu Nguyen
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Contributions

Conceptualization: HTTN, HTN and GTTD. Data Curation: GTTD, TTN, CTN and PA. Formal Analysis: HTN and THTP. Funding Acquisition: LB, GTV and RCMH. Methodology & Software: TTN, MR, HD and CSHH. Supervision: HTTN, LB and RCMH. Validation: LAD, HNV and CTN. Writing – Original: HTTN, HTN and THTP. Writing – Review & Editing: HTTN, LB, PA, HD, GTV, RCMH and CSHH. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Hien Thu Nguyen.

Ethics declarations

Competing interests

The authors declare no competing interests.

Ethics

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000. Approval was granted by the Scientific and Ethical Committee of Hanoi Obstetrics and Gynecology Hospital (No 1296/QĐ-PS). All participants provided their informed consent. All data has been anonymized to maintain confidentiality.

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Cite this article

Nguyen, H.T.T., Nguyen, H.T., Phan, T.H.T. et al. Prevalence and correlates of postpartum depression during the COVID-19 pandemic: a cross-sectional study in Vietnam. Sci Rep (2026). https://doi.org/10.1038/s41598-026-38669-3

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  • Received: 27 April 2025

  • Accepted: 30 January 2026

  • Published: 16 February 2026

  • DOI: https://doi.org/10.1038/s41598-026-38669-3

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Keywords

  • Postpartum depression
  • EPDS
  • COVID-19
  • Related factors
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