Abstract
Postpartum depression (PPD) is a common mental health issue that negatively impacts maternal well-being and infant development. The COVID-19 pandemic has exacerbated depression risk among postpartum women due to added stressors from the crisis. This study aimed to assess PPD prevalence during the pandemic and identify associated factors. The study was conducted at Hanoi Obstetrics and Gynecology Hospital from May 2023 to December 2023. This cross-sectional study selected 223 postpartum women via convenience sampling. Data collection utilized online surveys and phone interviews. The Edinburgh Postnatal Depression Scale (EPDS) gauged depression levels, analyzed using Stata 16.0. Descriptive statistics and logistic regression explored relationships between PPD and contributing factors. Among participants, 22.0% scored 9–11 on EPDS, indicating mild depression; 5.8% were high-risk (EPDS 12–13), and 8.5% had PPD (EPDS > 14). The study identified links between PPD and poor sleep, COVID-19 anxiety, and limited social support. PPD remains a critical concern during COVID-19, with factors like sleep quality, pandemic-related anxiety, and social support influencing depression risk. Early screening and psychological interventions are crucial to mitigate PPD’s impact on maternal and infant health post-pandemic.
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The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
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The authors would like to thank the Hanoi Obstetrics and Gynecology Hospital, the National University of Singapore, and the research collaborator.
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Conceptualization: HTTN, HTN and GTTD. Data Curation: GTTD, TTN, CTN and PA. Formal Analysis: HTN and THTP. Funding Acquisition: LB, GTV and RCMH. Methodology & Software: TTN, MR, HD and CSHH. Supervision: HTTN, LB and RCMH. Validation: LAD, HNV and CTN. Writing – Original: HTTN, HTN and THTP. Writing – Review & Editing: HTTN, LB, PA, HD, GTV, RCMH and CSHH. All authors read and approved the final manuscript.
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The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000. Approval was granted by the Scientific and Ethical Committee of Hanoi Obstetrics and Gynecology Hospital (No 1296/QĐ-PS). All participants provided their informed consent. All data has been anonymized to maintain confidentiality.
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Nguyen, H.T.T., Nguyen, H.T., Phan, T.H.T. et al. Prevalence and correlates of postpartum depression during the COVID-19 pandemic: a cross-sectional study in Vietnam. Sci Rep (2026). https://doi.org/10.1038/s41598-026-38669-3
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DOI: https://doi.org/10.1038/s41598-026-38669-3

