Table 3 Unadjusted and adjusted associations between independent variables and the odds for appendicitis in 177 children with suspected appendicitis.

From: Serum immunoglobulin A in pediatric appendicitis

 

cOR (95% CI)

p-value

aOR (95% CI)

p-value

Age (years)

0.96 (0.85–1.08)

0.499

  

Sex (male)

2.53 (1.23–5.20)

0.012

2.63 (1.24–5.56)a, b,c, d,e, f

0.012

Symptom duration (h)

0–24

Ref

Ref

Ref a, b, c, d, e, f

Ref

24–48

0.91 (0.39–2.12)

0.832

0.93 (0.39–2.21)

0.869

48–96

0.63 (0.24–1.66)

0.351

0.67 (0.25–1.81)

0.427

>96

0.12 (0.02–0.71)

0.020

0.14 (0.21–0.90)

0.039

Serum IgA (g/L)

0.72 (0.45–1.16)

0.177

0.70 (0.41–1.20) a

0.195

Age-dependent serum IgA*

Normal

Ref

Ref

Ref b

Ref

High

0.58 (0.10–3.35)

0.546

0.45 (0.05–3.83)

0.463

Low

1.08 (0-48-2.44)

0.855

1.27 (0.53-3.00)

0.592

CRP (mg/L)

1.01 (0.99–1.01)

0.295

1.01 (0.99–1.02)c

0.127

Leukocytes (x109/L)

1.17 (1.08–1.27)

< 0.001

1.17 (1.08–1.27)d

< 0.001

Neutrophils (x109/L)

1.21 (1.11–1.32)

< 0.001

1.21 (1.10–1.33)e

< 0.001

Neutrophil percentage (%)

1.07 (1.03–1.10)

< 0.001

1.07 (1.03–1.10)f

< 0.001

  1. *Serum IgA according to age-dependent reference intervals: 21 days – 2 years: 0.01–0.50 g/L, 2–10 years: 0.4–2.5 g/L, > 10 years: 0.88–4.5 g/L17.
  2. a, b,c, d,e, fIndicates which variables were included in each multivariable logistic regression analysis.
  3. The different inflammatory markers were included in the multivariable analysis with adjustment for sex and symptom duration one by one, and not considered potential confounders. The aOR: s for sex and symptom duration stem from the multivariable logistic regression analysis of serum IgA.
  4. cOR: crude odds ratio; aOR: adjusted odds ratio; CRP: C-reactive protein; IgA: immunoglobulin A.