Retraction of: Scientific Reports https://doi.org/10.1038/s41598-025-00222-z, published online 04 May 2025
The Authors have retracted this Article.
Following publication, concerns were raised regarding the robustness and reproducibility of the analyses of the mutational signature section presented in the study. Upon internal review, the Authors have identified issues that compromise the reliability of the reported findings:
-
1.
The de- novo mutation signature extraction method employed in the original study is not optimally suited for the specific somatic mutation data of Small Cell Lung Cancer (SCLC).
-
2.
The re-analysis indicated that methodological biases occurred during the processing and presentation of mutation signature activity and the subsequent integration of genomic with clinical data. These discrepancies led to results that are difficult to replicate with the necessary statistical robustness.
In light of these issues, the Authors no longer have confidence in the conclusions of the mutational signature section.
All Authors agree with the retraction and its wording.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
About this article
Cite this article
Li, Y., Song, C., Wang, H. et al. Retraction Note: Novel prognostic biomarkers in small cell lung cancer reveal mutational signatures, genomic mutations, and immune implications. Sci Rep 16, 6942 (2026). https://doi.org/10.1038/s41598-026-40190-6
Published:
Version of record:
DOI: https://doi.org/10.1038/s41598-026-40190-6
